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Titolo:
Inhibitory effect of vasoactive intestinal peptide on the challenge phase of allergic contact dermatitis in humans
Autore:
Lundeberg, L; Mutt, V; Nordlind, K;
Indirizzi:
Karolinska Hosp, Dept Dermatol, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 ol, SE-17176 Stockholm, Sweden Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden Karolinska Inst Stockholm Sweden d Biochem & Biophys, Stockholm, Sweden Univ Uppsala Hosp, Dept Dermatol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 rmatol, S-75185 Uppsala, Sweden
Titolo Testata:
ACTA DERMATO-VENEREOLOGICA
fascicolo: 3, volume: 79, anno: 1999,
pagine: 178 - 182
SICI:
0001-5555(199905)79:3<178:IEOVIP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; INTERFERON-GAMMA PRODUCTION; T-LYMPHOCYTE FUNCTION; CELLS; MODULATION; NEUROPEPTIDES; SEROTONIN; POLYPEPTIDE; EXPRESSION; IRRITANT;
Keywords:
5-HT; nickel sulphate; immunohistochemistry; lymphocyte transformation; ELISA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lundeberg, L Karolinska Hosp, Dept Dermatol, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
L. Lundeberg et al., "Inhibitory effect of vasoactive intestinal peptide on the challenge phase of allergic contact dermatitis in humans", ACT DER-VEN, 79(3), 1999, pp. 178-182

Abstract

There is increasing evidence that the nervous system has influence on the immune response. The effect of vasoactive intestinal peptide (VIP) and of serotonin and its antagonists on the challenge phase of allergic contact dermatitis in humans were tested. The substances were injected intracutaneously shortly before and 6 h after application of patch tests with nickel sulphate in nickel-allergic patients and the test areas were measured after a further 18 h, Biopsy specimens were also taken for immunohistochemistry. The diameter of the nickel sulphate-induced test reaction was significantly reduced after injection of VIP at 10(-6)-10(-5) mol/l, but was not affected byserotonin or ketanserin. Also tested was the influence of the substances on the response of peripheral blood mononuclear cells from nickel-allergic subjects to nickel sulphate, when added at the same time as the antigen. No effect on the cell proliferative rate was seen, except for an inhibitory effect of serotonin and its antagonists at 10(-5)-10(-4) mol/l. VIP, at 10(-5) mol/l and serotonin at 10(-4) mol/l stimulated the secretion of interferon gamma. The interleukin-2 soluble receptor secretion was slightly stimulated by 5-HT at 10-4 mol/l and by ketanserin at 10(-6) mol/l. In conclusion, our results show that when injected intracutaneously in the challenge phaseof allergic contact dermatitis, VIP has an inhibitory effect, which might be explained by enhanced leukocyte production of interferon gamma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:12:55