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Titolo:
Kidney preservation in the next millenium
Autore:
Stubenitsky, BM; Booster, MH; Nederstigt, AP; Kievit, JK; Jacobs, RWA; Kootstra, G;
Indirizzi:
UnivNetherlandsricht, Dept Surg, Preservat Res Grp, NL-6202 AZ Maastricht,Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ 02 AZ Maastricht,
Titolo Testata:
TRANSPLANT INTERNATIONAL
fascicolo: 2, volume: 12, anno: 1999,
pagine: 83 - 91
SICI:
0934-0874(199903)12:2<83:KPITNM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-BEATING DONORS; PYRIDOXALATED-HEMOGLOBIN-POLYOXYETHYLENE; MACHINE PERFUSION PRESERVATION; GLUTATHIONE-S-TRANSFERASE; DELAYED GRAFT FUNCTION; STROMA-FREE HEMOGLOBIN; RENAL-TRANSPLANTATION; VIABILITY ASSESSMENT; DAMAGED KIDNEYS; COLD-STORAGE;
Keywords:
kidney preservation; viability testing; ischemia; non-heart-beating donor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Stubenitsky, BM Univastricht,stricht, Dept Surg, Preservat Res Grp, POB 5800, NL-6202 AZ Ma Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
B.M. Stubenitsky et al., "Kidney preservation in the next millenium", TRANSPLAN I, 12(2), 1999, pp. 83-91

Abstract

For the past decades, severe hypothermia has represented the foundation oforgan preservation in clinical transplantation. Beneficial as hypothermia has proven to be in preserving grafts from heart-beating donors, hypothermia does not seem to provide the window necessary for the prospective evaluation of organ function. With the increasing use of non-heart-beating donors,it is logical to propose that if organs are to be evaluated prospectively,it will be necessary to preserve them at warmer temperatures. Since both glomerular and tubular functions are inhibited at temperatures below 18 degrees C, such a goal will necessitate organ preservation at a temperature above 20 degrees C. The principle of preservation at warmer temperatures is not new, but with future developments and approaches, successful realization appears within reach. In this overview, a brief history of previous attempts at warm preservation, in the context of the current status of kidney preservation, is presented. Future developments and approaches, with the potential for prospective testing of the function and enhanced resistance to ischemic damage, will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:54:44