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Titolo:
HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations
Autore:
Spurkland, A; Saarinen, S; Boberg, KM; Mitchell, S; Broome, U; Caballeria, L; Ciusani, E; Chapman, R; Ercilla, G; Fausa, O; Knutsen, I; Pares, A; Rosina, F; Olerup, O; Thorsby, E; Schrumpf, E;
Indirizzi:
Natl Hosp Norway, Inst Immunol, N-0027 Oslo, Norway Natl Hosp Norway Oslo Norway N-0027 y, Inst Immunol, N-0027 Oslo, Norway Karolinskaholm,, Huddinge Hosp, Unit Gastroenterol & Hepatol, S-10401 Stock Karolinska Inst Stockholm Sweden S-10401 nterol & Hepatol, S-10401 Stock Molinette Mauriziano Hosp, Dept Gastroenterol, Turin, Italy Molinette Mauriziano Hosp Turin Italy Dept Gastroenterol, Turin, Italy John Radcliffe Hosp, Dept Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England Univ Barcelona, Hosp Clin & Prov, Liver Unit, Barcelona, Spain Univ Barcelona Barcelona Spain lin & Prov, Liver Unit, Barcelona, Spain Univ Barcelona, Hosp Clin & Prov, Serv Immunol, Barcelona, Spain Univ Barcelona Barcelona Spain n & Prov, Serv Immunol, Barcelona, Spain Inst Naz Neurol, Dept Neurol, Milan, Italy Inst Naz Neurol Milan ItalyInst Naz Neurol, Dept Neurol, Milan, Italy Univ Oslo, Natl Hosp, Dept Med, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Dept Med, Oslo, Norway
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 5, volume: 53, anno: 1999,
pagine: 459 - 469
SICI:
0001-2815(199905)53:5<459:HCIHIP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; CELIAC-DISEASE; GENETIC-MARKERS; CROHNS-DISEASE; SUSCEPTIBILITY; ASSOCIATION; DQ; HLA-DRW52A; ANTIGENS;
Keywords:
disease susceptibility genes; HLA class II genes; primary sclerosing cholangitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Spurkland, A Natl Hosp Norway, Inst Immunol, N-0027 Oslo, Norway Natl HospNorway Oslo Norway N-0027 ol, N-0027 Oslo, Norway
Citazione:
A. Spurkland et al., "HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations", TISSUE ANTI, 53(5), 1999, pp. 459-469

Abstract

The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1"0501, DQB1*02 (RR=3.0, P<0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR=2.4, P<0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR=20, P<0.0001). The DRB1*04,DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR=0.4, P<0.00001). Among Nor wegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1"0501, DQB1*02 nor die DRB1*13 DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplotype was observed (RR=2.0, P<0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:16:06