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Titolo:
Superoxide dismutase activity and the effect of N-methly-D-aspartate antagonists on lipid peroxidation in the early phase of cold injury
Autore:
Kiris, T; Gorgulu, A; Unal, F; Turkoglu, U; Cobanoglu, S; Ekuklu, G;
Indirizzi:
Trakya Univ, Sch Med, Dept Neurosurg, TR-22030 Edirne, Turkey Trakya UnivEdirne Turkey TR-22030 pt Neurosurg, TR-22030 Edirne, Turkey Istanbul Univ, Sch Med, Dept Biochem, TR-34390 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34390 iochem, TR-34390 Istanbul, Turkey Trakya Univ, Sch Med, Dept Publ Hlth, TR-22030 Edirne, Turkey Trakya UnivEdirne Turkey TR-22030 pt Publ Hlth, TR-22030 Edirne, Turkey Istanbul Univ, Sch Med, Dept Neurosurg, TR-34390 Istanbul, Turkey IstanbulUniv Istanbul Turkey TR-34390 rosurg, TR-34390 Istanbul, Turkey
Titolo Testata:
RESEARCH IN EXPERIMENTAL MEDICINE
fascicolo: 6, volume: 198, anno: 1999,
pagine: 341 - 347
SICI:
0300-9130(199904)198:6<341:SDAATE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD INJURY; VASOGENIC BRAIN EDEMA; OXYGEN FREE-RADICALS; AMINO-ACID RELEASE; NEUROLOGICAL DISORDERS; ISCHEMIA; EXCITOTOXICITY; INVOLVEMENT; GLUTAMATE; RECEPTORS;
Keywords:
cold injury; lipid peroxidation; MK-801; NMDA antagonist; superoxide dismutase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kiris, T Atakoy 5 Kisim D8 Blok Daire 8, TR-34750 Istanbul, Turkey Atakoy5 Kisim D8 Blok Daire 8 Istanbul Turkey TR-34750 Turkey
Citazione:
T. Kiris et al., "Superoxide dismutase activity and the effect of N-methly-D-aspartate antagonists on lipid peroxidation in the early phase of cold injury", RES EXP MED, 198(6), 1999, pp. 341-347

Abstract

Free radicals, lipid peroxidation and excitatory amino acids have been implicated in the secondary mechanisms of traumatic brain injury. We used the cold injury model in rats to assess the endogenous activity of the protective enzyme superoxide dismutase (SOD) and the lipid peroxidation level in the contused tissue at an early phase of injury. Furthermore, we treated the rats with two different N-methyl-D-aspartate receptor antagonists, namely MK-801 and CPP, and evaluated their effect on lipid peroxidation in the contused tissue. Rats were divided into four groups: sham, control, treatment 1and treatment 2 groups (n = 16 for each group). Thirty and 60 min after craniectomy or injury, tissue samples were removed. SOD activity didn't change in this period. However, lipid peroxidation in terms of malondialdehyde (MDA) amount showed a significant increase at 60 min. Fifteen minutes after injury, MK-801 (1 mg/kg), CPP (10 mg/kg) or saline (1 ml) were applied intraperitoneally in treatment 1, treatment 2 and the control groups, Treatmentwith MK-801 attenuated MDA levels, whereas treatment with CPP did not. Theprotective effect of MK-801 achieved statistical significance. These results demonstrate that SOD activity does not change in the Parry period of cold injury. Moreover, these results show that lipid peroxidation increases after 60 min of cold injury, and treatment with MK-801 15 min after injury can prevent this elevation.

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Documento generato il 25/01/20 alle ore 15:59:19