Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Glial neoplasms: Dynamic contrast-enhanced T2*-weighted MR imaging
Autore:
Knopp, EA; Cha, S; Johnson, G; Mazumdar, A; Golfinos, JG; Zagzag, D; Miller, DC; Kelly, PJ; Kricheff, II;
Indirizzi:
NYU, Med Ctr, Dept Radiol, New York, NY 10016 USA NYU New York NY USA 10016 U, Med Ctr, Dept Radiol, New York, NY 10016 USA NYU, Med Ctr, Dept Neurosurg, New York, NY 10016 USA NYU New York NY USA 10016 Med Ctr, Dept Neurosurg, New York, NY 10016 USA NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA NYU New York NY USA 10016 U, Med Ctr, Dept Pathol, New York, NY 10016 USA NYU, Med Ctr, Kaplan Comprehens Canc Ctr, New York, NY 10016 USA NYU New York NY USA 10016 lan Comprehens Canc Ctr, New York, NY 10016 USA
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 211, anno: 1999,
pagine: 791 - 798
SICI:
0033-8419(199906)211:3<791:GNDCTM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; ANAPLASTIC ASTROCYTOMA; GADOLINIUM-DTPA; PERFUSION; EXPRESSION;
Keywords:
astrocytoma; brain neoplasms, diagnosis; brain neoplasms, MR; brain, perfusion; magnetic resonance (MR), perfusion study; stereotaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Knopp, EA NYU, Med Ctr, Dept Radiol, 560 1St Ave, New York, NY 10016 USA NYU 560 1St Ave New York NY USA 10016 ve, New York, NY 10016 USA
Citazione:
E.A. Knopp et al., "Glial neoplasms: Dynamic contrast-enhanced T2*-weighted MR imaging", RADIOLOGY, 211(3), 1999, pp. 791-798

Abstract

PURPOSE: To evaluate the role of T2*-weighted echo-planar perfusion imaging by ;- using a first-pass gadopentetate dimeglumine technique to determinethe association of magnetic resonance (MR) imaging-derived cerebral blood volume(CBV) maps with histopathologic grading of astrocytomas and to improve the accuracy of targeting of stereotactic biopsy. MATERIALS AND METHODS: MR imaging was performed in 29 patients by using a first-pass gadopentetate dimeglumine; T2*-weighted; echo-planar perfusion sequence followed by conventional imaging. The perfusion data were processedto obtain a color map of relative regional CBV;This information formed;thebasis for targeting the stereotactic biopsy. Relative CBV values were computed with a nondiffusible tracer model. the relative CBV of-lesions was expressed;ed a; a percentage of the relative CBV of normal white matter. The maximum relative CBV of each lesion was correlated with the histopathologic grading of astrocytomas obtained from samples from stereotactic biopsy or volumetric resection. RESULTS: The maximum relative CV in high-grade astrocytomas (n = 26) varied from 1.73 to 13.7,with a;mean of 5,07 +/- 2.79 (+/- SD), and in the low-grade cohort (n = 3) varied from 0.92 to 2.19, with a mean:of 1.44 +/- 0.68. This difference in relative CBV was statistically significant (P <.001; Student t test)CONCLUSION:Echo-planar, perfusion imaging is useful inthepreoperative assessment of tumor grade and in providing diagnostic information not availablewith conventional MR imaging. The areas of perfusion abnormality are invaluable in the precise targeting of the stereotactic biopsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:49:06