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Titolo:
Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: Comparison with Tc-99m-DTPA autoradiography in rats
Autore:
Arheden, H; Saeed, M; Higgins, CB; Gao, DW; Bremerich, J; Wyttenbach, R; Dae, MW; Wendland, MF;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 211, anno: 1999,
pagine: 698 - 708
SICI:
0033-8419(199906)211:3<698:MOTDVO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVERSION-RECOVERY EPI; GD-DTPA; TECHNETIUM-99M DTPA; EXTRACELLULAR-SPACE; TRIPHENYLTETRAZOLIUM CHLORIDE; CONTRAST ENHANCEMENT; VIABLE MYOCARDIUM; RABBIT HEART; REPERFUSION; TISSUE;
Keywords:
heart, experimental studies; magnetic resonance (MR), contrast enhancement; magnetic resonance (MR), echo planar; myocardium, infarction; myocardium, ischemia; radionuclide imaging, experimental studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Higgins, CB Univisco,f San Francisco, Dept Radiol, 505 Parnassus Ave,Rm L308, San Franc Univ Calif San Francisco 505 Parnassus Ave,Rm L308 San Francisco CA USA 94143
Citazione:
H. Arheden et al., "Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: Comparison with Tc-99m-DTPA autoradiography in rats", RADIOLOGY, 211(3), 1999, pp. 698-708

Abstract

PURPOSE: To measure the fractional distribution volume of gadopentetate dimeglumine in normal and reperfused infarcted myocardium at magnetic resonance (MR) imaging by using the fractional distribution volume of technetium 99m-diethylenetriaminepentaacetic acid (DTPA) as an independent reference. MATERIALS AND METHODS: Rats were subjected to 1 hour of coronary artery occlusion and 1 hour of reperfusion before inversion-recovery echo-planar imaging or autoradiography. Regional change in relaxation rate (Delta R1) ratios for myocardium over blood were compared with radioactivity ratios for myocardium over blood after the injection of (TC)-T-99m-DTPA. RESULTS: Both Delta R1 and radioactivity ratios demonstrated equilibrium distribution and hence represent partition coefficients (lambda). The fractional distribution volumes were greater in infarcted myocardium (0.90 +/- 0.05 for gadopentetate dimeglumine and 0.89 +/- 0.04 for Tc-99m-DTPA) than Innormal myocardium (0.23 +/- 0.02 for gadopentetate dimeglumine and 0.16 +/- 0.01 for Tc-99m-DTPA). Area at risk at autoradiography was not significantly different from that at histomorphometry. The infarction size defined byusing triphenyltetrazolium chloride was 13% +/- 4 smaller than that defined by using autoradiography. CONCLUSION: The fractional distribution volumes of gadopentetate dimeglumine and Tc-99m-DTPA are similar and indicate extracellular distribution in normal myocardium and intracellular as well as extracellular distribution inreperfused infarction. Because the failure of cells to exclude these agents is indicative of necrosis, contrast medium-enhanced MR imaging may be useful to quantify myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:12:20