Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacokinetic imaging of C-11 ethanol with PET in eight patients with hepatocellular carcinomas who were scheduled for treatment with percutaneous ethanol injection
Autore:
Dimitrakopoulou-Strauss, A; Strauss, LG; Gutzler, F; Irngartinger, G; Kontaxakis, G; Kim, DK; Oberdorfer, F; van Kaick, G;
Indirizzi:
Germanidelberg, Ctr, Dept Oncol Diagnost & Therapy, Med PET Grp, D-69120 He German Canc Res Ctr Heidelberg Germany D-69120 , Med PET Grp, D-69120 He GermanHeidelberg,tr, Dept Radiochem & Radiopharmacol, Med PET Grp, D-69120German Canc Res Ctr Heidelberg Germany D-69120 col, Med PET Grp, D-69120 Univ Heidelberg, Dept Internal Med 4, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Dong A Univ, Dept Nucl Med, Pusan, South Korea Dong A Univ Pusan South Korea A Univ, Dept Nucl Med, Pusan, South Korea
Titolo Testata:
RADIOLOGY
fascicolo: 3, volume: 211, anno: 1999,
pagine: 681 - 686
SICI:
0033-8419(199906)211:3<681:PIOCEW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVER METASTASES; COLORECTAL-CARCINOMA; TUMOR METABOLISM; ABLATION THERAPY;
Keywords:
alcohol; liver neoplasms, chemotherapeutic infusion; liver neoplasms, radionuclide studies; liver neoplasms, therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dimitrakopoulou-Strauss, A Germanidelberg, Ctr, Dept Oncol Diagnost & Therapy, Med PET Grp, D-69120 He German Canc Res Ctr Heidelberg Germany D-69120
Citazione:
A. Dimitrakopoulou-Strauss et al., "Pharmacokinetic imaging of C-11 ethanol with PET in eight patients with hepatocellular carcinomas who were scheduled for treatment with percutaneous ethanol injection", RADIOLOGY, 211(3), 1999, pp. 681-686

Abstract

PURPOSE: To evaluate the carbon 11 ethanol kinetics with positron emissiontomography after intratumoral injection of the tracer and assess its redistribution and dilution in patients who have hepatocellular carcinomas and who were scheduled for treatment with percutaneous ethanol injection. MATERIALS AND METHODS: The study included eight patients with hepatocellular carcinomas. C-11 ethanol was administered via a puncture needle positioned with ultrasonographic guidance. Parametric images based on the Fourier transformation were created for further analysis of the local distribution patterns of the tracer. The ratio of the 45-minute postinjection standardized uptake value to the 5-minute postinjection standardized uptake value was used for the evaluation of ethanol dilution. RESULTS: Five of eight tumors demonstrated almost constant uptake values after the initial distribution phase. In contrast, a rapid elimination of the C-11 ethanol from the tumor was documented in three of sight tumors. The 45 minute-to-5 minute ratio was 0.18-0.67 (median value, 0.56) in the tumors. The time-activity curves of the normal liver parenchyma increased slowlybut steadily with time owing to a low ethanol elimination from the tumor. Fourier transformation demonstrated inhomogeneous parts on the amplitude images in seven of eight tumors and random redistribution on the phase imagesin six of eight tumors. CONCLUSION: Inhomogeneous drug distribution and drug dilution in the target area are likely to be the major limiting parameters for therapy response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:05:13