Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serotonin and externalizing behavior in young children
Autore:
Clarke, RA; Murphy, DL; Constantino, JN;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA NIMH, Clin Sci Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Clin Sci Lab, Bethesda, MD 20892 USA Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Pediat, St Louis, MO 63110 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 1, volume: 86, anno: 1999,
pagine: 29 - 40
SICI:
0165-1781(19990419)86:1<29:SAEBIY>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; ANTISOCIAL PERSONALITY-DISORDER; LOW CSF 5-HIAA; RHESUS-MONKEYS; AGGRESSIVE-BEHAVIOR; 5-HYDROXYINDOLEACETIC ACID; REUPTAKE INHIBITORS; CIRCUMPLEX MODEL; SOCIAL-BEHAVIOR; FAMILY HISTORY;
Keywords:
5-hydroxyindoleacetic acid (5-HIAA); aggression; family environment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Constantino, JN Washington110iv, Sch Med, Dept Psychiat, 4940 Childrens Pl, St Louis, MO 63 Washington Univ 4940 Childrens Pl St Louis MO USA 63110 63
Citazione:
R.A. Clarke et al., "Serotonin and externalizing behavior in young children", PSYCHIAT R, 86(1), 1999, pp. 29-40

Abstract

Considerable evidence suggests that there is a relationship between pathologic aggressive behavior and low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in both humans and non-human primates. The purpose of this investigation is to examine the relationship between CSF concentrations of human newborn 5-HIAA and subsequent aggressive behavior observed at 30 months of age. Leftover portionsof culture negative CSF drawn from febrile infants (age, birth to 3 months) were assayed for 5-HIAA. Family environment and child behavior were assessed at 30 months by parent report. Subjects with 5-HIAA levels below the median of the distribution had higher externalizing behavior scores at 30 months than did subjects whose 5-HIAA levels fell above the median (P = 0.02). While it is likely that serotonin mediates one component of genetic liability to antisocial outcome, the magnitude of that component may be less thanwhat has been inferred from previously published reports. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 15:01:24