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Titolo:
Transcellular uptake mechanisms of the intestinal epithelial barrier - Part one
Autore:
Daugherty, AL; Mrsny, RJ;
Indirizzi:
Genentechncisco,ept Pharmaceut Res & Dev, Drug Delivery Biol Grp, S San Fra Genentech Inc S San Francisco CA USA 94080 g Delivery Biol Grp, S San Fra
Titolo Testata:
PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY
fascicolo: 4, volume: 2, anno: 1999,
pagine: 144 - 151
SICI:
1461-5347(199904)2:4<144:TUMOTI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CACO-2 CELL MONOLAYERS; DRUG ABSORPTION; IN-VITRO; TRANSEPITHELIAL TRANSPORT; PROTEASE INHIBITORS; PEPTIDE TRANSPORTER; ORAL ABSORPTION; DELIVERY; PERMEABILITY; PROTEINS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Daugherty, AL Genentech,Inc, Dept Pharmaceut Res & Dev, Drug Delivery BiolGrp, 1 DNA Way Genentech Inc 1 DNA Way S San Francisco CA USA 94080 DNA Way
Citazione:
A.L. Daugherty e R.J. Mrsny, "Transcellular uptake mechanisms of the intestinal epithelial barrier - Part one", PHARM SCI T, 2(4), 1999, pp. 144-151

Abstract

Part one of this two-part review addresses the transport of therapeutics across the intestinal barrier, and focuses on transcellular transport through the intestinal epithelia. The anatomical, biochemical and physiological parameters impacting transcellular uptake of orally administered drugs are described, and methods for overcoming obstacles limiting successful transcellular oral drug delivery are discussed. Part two will cover paracellular transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:38:21