Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
High yield synthesis of [C-11]-acetone through selective quenching of methyl lithium
Autore:
Studenov, AR; Berridge, MS; Soloviev, DV; Matarrese, M; Todde, S;
Indirizzi:
Univ Hosp Cleveland, Dept Radiol, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 adiol, Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Milan, CNR, INB, Sci Inst HC Raffaele, Milan, Italy Univ Milan Milan Italy an, CNR, INB, Sci Inst HC Raffaele, Milan, Italy
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 4, volume: 26, anno: 1999,
pagine: 431 - 435
SICI:
0969-8051(199905)26:4<431:HYSO[T>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
KETONES;
Keywords:
methyllithium; acetone; carbon-11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, MS Univ Hosp Cleveland, Dept Radiol, 11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA 44106 A
Citazione:
A.R. Studenov et al., "High yield synthesis of [C-11]-acetone through selective quenching of methyl lithium", NUCL MED BI, 26(4), 1999, pp. 431-435

Abstract

Carbon-11 labeled acetone is a useful radiosynthetic precursor. Previously, strict control of no-carrier-added stoichiometry was required to prepare it from reaction of CO2 and methyl lithium. However, excess methyl lithium may be selectively quenched to avoid reaction with nascent acetone to give tert-butanol. We report a simple pKa-based strategy to sequentially and selectively quench MeLi and acetone to give yields of up to 100% acetone even in the presence of a large excess of MeLi. The method gives good yields of acetone under conditions that previously precluded its synthesis. NUCL MED BIOL 26;4:431-435, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:29:06