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Titolo:
The impact of diabetes on CNS - Role of bioenergetic defects
Autore:
Kaur, G; Bhardwaj, SK;
Indirizzi:
Gurutsarak Dev Univ, Dept Biotechnol, Neurochem & Neuroendocrinol Lab, Amri Guru Nanak Dev Univ Amritsar Punjab India 143005 euroendocrinol Lab, Amri
Titolo Testata:
MOLECULAR AND CHEMICAL NEUROPATHOLOGY
fascicolo: 1-3, volume: 35, anno: 1998,
pagine: 119 - 131
SICI:
1044-7393(199808/12)35:1-3<119:TIODOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; ENERGY-METABOLISM; ALZHEIMERS-DISEASE; COMPLEX-I; CYTOCHROME-OXIDASE; PARKINSONS-DISEASE; NERVOUS-SYSTEM; RAT-BRAIN; OXIDOREDUCTASE; MITOCHONDRIA;
Keywords:
diabetes; mitochondria; bioenergetic defects; electron transport chain; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Kaur, G Gurutsarak Dev Univ, Dept Biotechnol, Neurochem & Neuroendocrinol Lab, Amri Guru Nanak Dev Univ Amritsar Punjab India 143005 crinol Lab, Amri
Citazione:
G. Kaur e S.K. Bhardwaj, "The impact of diabetes on CNS - Role of bioenergetic defects", MOL CHEM NE, 35(1-3), 1998, pp. 119-131

Abstract

To address the problem of the pathogenesis in diabetic neuropathy, rats were made diabetic by streptozotocin administration, and discrete brain regions, such as cortex, cerebellum, brainstem, thalamus, and hypothalamus, weresampled for assay of activities of electron transport chain complexes I-IVat 1 and 3 mo after induction of diabetes. Significant decrease was seen in activities of dinitrophenylhydrazine DNPH-coenzyme Q reductase (complex I), coenzyme Q cytochrome-e reductase (complex III), and cytockrome-c oxidase (complex IV) from discrete brain regions with more pronounced changes in complex I. The decline in the complex I, III, and IV activity was more severe in the 3-mo group. Succinate dehydrogenase (SDH) coenzyme Q reductase (complex II), which is an enzyme shared by tricarboxylic acid (TCA) cycle andelectron transport chain, showed a significant increase under the same setof conditions. These results suggest that the bioenergetic impairment has an important role in the pathophysiology of diabetes.

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Documento generato il 18/01/20 alle ore 10:35:46