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Titolo:
Regulation of the size and distribution of agrin-induced postsynaptic-likeapparatus in adult skeletal muscle by electrical muscle activity
Autore:
Mathiesen, I; Rimer, M; Ashtari, O; Cohen, I; McMahan, UJ; Lomo, T;
Indirizzi:
Univ Oslo, Dept Physiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Dept Physiol, Oslo, Norway Stanford Univ, Dept Neurobiol, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 biol, Sch Med, Stanford, CA 94305 USA
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 1999,
pagine: 207 - 217
SICI:
1044-7431(199903)13:3<207:ROTSAD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NEUROMUSCULAR SYNAPSES; RECEPTOR GENE-EXPRESSION; ACETYLCHOLINE-RECEPTORS; METABOLIC STABILIZATION; MUSCULAR INFLUENCES; INNERVATED MUSCLE; IN-VIVO; JUNCTIONS; NEUREGULINS; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mathiesen, I Univ Oslo, Dept Physiol, Oslo, Norway Univ Oslo Oslo Norway niv Oslo, Dept Physiol, Oslo, Norway
Citazione:
I. Mathiesen et al., "Regulation of the size and distribution of agrin-induced postsynaptic-likeapparatus in adult skeletal muscle by electrical muscle activity", MOL CELL NE, 13(3), 1999, pp. 207-217

Abstract

We compared actylcholine receptor (AChR) aggregates induced by neural agrin released from transfected muscle fibers with ACI IR aggregates induced bytransplanted axons in extrajunctional regions of denervated rat soleus muscles. Both neural agrin and transplanted axons induced multiple, irregularly distributed AChR aggregates on muscle fibers. Direct electrical muscle stimulation of transfected muscles for up to 10 weeks removed all agrin-induced AChR aggregates (the losers) except one (the winner) on many fibers. Axon-induced AChR aggregates underwent comparable selection of winners and losers. The results suggest that agrin and acetylcholine-driven muscle activity provided by transplanted axons are sufficient to elicit in a denervated adult muscle fiber processes that regulate the size and distribution of ectopic neuromuscular junctions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:11:07