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Titolo:
Regulation of the size and distribution of ectopic neuromuscular junctionsin adult skeletal muscle by nerve-derived trophic factor and electrical muscle activity
Autore:
Skorpen, J; Lafond-Benestad, S; Lomo, T;
Indirizzi:
Univ Oslo, Dept Physiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Dept Physiol, Oslo, Norway
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 13, anno: 1999,
pagine: 192 - 206
SICI:
1044-7431(199903)13:3<192:ROTSAD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SOLEUS MUSCLE; ACETYLCHOLINE-RECEPTORS; METABOLIC STABILIZATION; MUSCULAR INFLUENCES; SYNAPSES; ELIMINATION; SENSITIVITY; CELLS; TERMINALS; NUMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Skorpen, J Univ Oslo, Dept Physiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Dept Physiol, Oslo, Norway
Citazione:
J. Skorpen et al., "Regulation of the size and distribution of ectopic neuromuscular junctionsin adult skeletal muscle by nerve-derived trophic factor and electrical muscle activity", MOL CELL NE, 13(3), 1999, pp. 192-206

Abstract

Transplanted axons induced multiple, irregularly distributed acetylcholinereceptor (AChR) aggregates on muscle fibers at early stages of ectopic neuromuscular junction formation in denervated adult rat soleus muscles. Subsequently, most AChR aggregates disappeared (the losers). A few aggregates survived (the winners) and, as part of the surviving junctions, reached a certain size and spatial separation along the fibers. This elimination of losers and development of winners occurred only in electrically active muscles whether the activity was elicited by intact axons or by electrical muscle stimulation after the axons had been cut early. We conclude that electrical muscle activity regulates the size and distribution of ectopic neuromuscular junctions by acting in conjunction with a nerve-derived priming influencethat does not require the continued presence of nerve terminals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:05:31