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Titolo:
A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature
Autore:
Paal, E; Thompson, LDR; Przygodzki, RM; Bratthauer, GL; Heffess, CS;
Indirizzi:
Armedadorces Inst Pathol, Div Endocrine, Dept Endocrine & Otorhinolaryng He Armed Forces Inst Pathol Washington DC USA 20306 rine & Otorhinolaryng He Armed Forces Inst Pathol, Dept Cellular Pathol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA Armed Forces Inst Pathol, Sci Labs, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA Armedathol,s Inst Pathol, Dept Infect & Parasit Dis Pathol, Amer Registry P Armed Forces Inst Pathol Washington DC USA 20306 Pathol, Amer Registry P
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 5, volume: 12, anno: 1999,
pagine: 518 - 528
SICI:
0893-3952(199905)12:5<518:ACAISO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-RAS GENES; CELL-CYCLE; HYPERSECRETING NEOPLASMS; DUCTAL ECTASIA; HER-2/NEU EXPRESSION; CYSTIC NEOPLASMS; POINT MUTATIONS; BREAST-CANCER; P53 MUTATIONS; TUMORS;
Keywords:
immunohistochemistry; intraductal; mucinous; neoplasms; pancreas; papillary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Heffess, CS Armedadorces Inst Pathol, Div Endocrine, Dept Endocrine & Otorhinolaryng He Armed Forces Inst Pathol Bldg 54,Room G066-9,6825 16th St NW Washington DC USA 20306
Citazione:
E. Paal et al., "A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature", MOD PATHOL, 12(5), 1999, pp. 518-528

Abstract

Intraductal papillary-mucinous neoplasms (IPMNs) of the pancreas are rare lesions. We undertook this study to analyze these tumors by focusing on thediagnostic criteria and correlating the histologic features with clinical prognosis. Twenty-two cases of IPMN were retrieved from the Endocrine TumorRegistry of the Armed Forces Institute of Pathology. Blocks or unstained slides were available for histochemical and immunohistochemical studies (including proliferative markers and cell cycle regulators) and K-ras oncogene mutations in 15 cases. Patient follow-up was obtained in all of the cases. IPMN occurs in both genders with a slight male predominance, with a mean age at presentation of 64.4 years (range, 48-85 yr). The patients presented with abdominal pain. The neoplasms were radiologically and grossly cystic, usually (18 cases of 22) located in the head of the pancreas. Histologically, the tumors consisted of intraductal papillary proliferations protruding into and expanding the pancreatic ducts. Invasion into the surrounding pancreatic parenchyma was detected in 15 cases. Chronic pancreatitis was presentin all of the cases. p27 immunoreactivity always exceeded the immunoreactivity of cyclin E. K-ras oncogene mutations were detected in two cases. Patients were treated with a complete surgical resection (n = 7) or a Whipple procedure (n = 13), Only 2 of 22 patients died of disease (3 died immediately postoperatively and 3 died of unrelated causes), whereas the remaining 14patients were alive at last follow-up, without evidence of disease, an average of 58.2 months after initial presentation. IPMNs are rare, distinctiveneoplasms, with complex intraductal papillae, that can be easily separatedfrom in sift ductal adenocarcinoma and mucinous cystic neoplasms, The highratio of p27 protein to cyclin E supports the excellent prognosis of theseneoplasms, despite the presence of invasion and K-ras oncogene mutation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:25:18