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Titolo:
Tli1, a resistance locus for carcinogen-induced T-lymphoma
Autore:
Wielowieyski, A; Brennan, LA; Jongstra, J;
Indirizzi:
UnivNToronto, Arthrit Ctr Excellence, Toronto Hosp, Western Div, Toronto, O Univ Toronto Toronto ON Canada M5T 2S8 onto Hosp, Western Div, Toronto, O UnivaToronto, Arthrit & Immune Disorder Res Ctr, Toronto, ON M5T 2S8, Canad Univ Toronto Toronto ON Canada M5T 2S8 es Ctr, Toronto, ON M5T 2S8, Canad Univ Toronto, Dept Immunol, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 munol, Toronto, ON M5T 2S8, Canada
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 6, volume: 10, anno: 1999,
pagine: 623 - 627
SICI:
0938-8990(199906)10:6<623:TARLFC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-N-NITROSOUREA; MURINE LEUKEMIA-VIRUS; THYMIC LYMPHOMAS; MICE; GENE; PROVIRUSES; INDUCTION; THYMOMAS; ADDUCTS; MATURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Jongstra, J Univ9,399nto, Arthrit Ctr Excellence, Toronto Hosp, Western Div, Room 13-41 Univ Toronto Room 13-419,399 Bathurst St Toronto ON Canada M5T 2S8
Citazione:
A. Wielowieyski et al., "Tli1, a resistance locus for carcinogen-induced T-lymphoma", MAMM GENOME, 10(6), 1999, pp. 623-627

Abstract

Within 180 days after injection with N-methyl-N-nitrosourea (MNU), 83.5% of AKR/J mice and 37.5% of BALB/cJ mice developed T-lymphoma. The high tumorincidence was a dominant trait, as 93% of MNU-injected F-1 mice developed T-lymphoma. A genome screen of 285 MNU-injected F-2 mice identified a locus, designated T-lymphoma Induced 1 or Tli1, in a similar to 10-cM interval on central Chr 1 between D1Mit87 and D1Mit423 with significant linkage to the incidence of MNU-induced T-lymphoma (P = 0.0004). Injection of BALB/cJ.AKR/J-Tli1 congenic mice with MNU confirmed the presence of Tli1 on central Chr 1. Mice homozygous for the BALB/cJ allele (Tli1(bb)) were over-represented in the tumor-free F-2 mice, while the inheritance of parental alleles ofTli1 in turner-bearing mice was close to expected. This suggests that the Tli1(b) allele is recessive and suppresses MNU-induced T-lymphoma development in BALB/cJ mice and in Tli1(bb) F-2 mice. Furthermore, the kinetics of lymphoma development in BALB/cJ and the Tli1 congenic mice suggests that Tli1(b) acts to suppress lymphomas developing late after injection with MNU. Two known genes that map in the identified genomic interval on central Chr 1are candidates for Tli1:IL10, encoding the lymphokine IL10, and Cmkar4, encoding the chemokine receptor CXCR4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:13:41