Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
Autore:
Schmidt, MI; Duncan, BB; Sharrett, AR; Lindberg, G; Savage, PJ; Offenbacher, S; Azambuja, MI; Tracy, RP; Heiss, G;
Indirizzi:
UFRGS, Sch Med, Dept Social Med, BR-90035003 Porto Alegre, RS, Brazil UFRGS Porto Alegre RS Brazil BR-90035003 BC35003 Porto Alegre, RS, Brazil Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA Univ NCarolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina, Sch Dent, Dent Res Ctr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA nt, Dent Res Ctr, Chapel Hill, NC USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Malmo Hosp, NEPI Fdn, Malmo, Sweden Malmo Hosp Malmo SwedenMalmo Hosp, NEPI Fdn, Malmo, Sweden Univ Vermont, Dept Pathol & Biochem, Colchester, VT USA Univ Vermont Colchester VT USA Dept Pathol & Biochem, Colchester, VT USA
Titolo Testata:
LANCET
fascicolo: 9165, volume: 353, anno: 1999,
pagine: 1649 - 1652
SICI:
0140-6736(19990515)353:9165<1649:MOIAPO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; INNATE IMMUNE-SYSTEM; CARDIOVASCULAR-DISEASE; OBESITY; ASSOCIATION; EXPRESSION; LEPTIN; NIDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, MI UFRGS,legre,ed, Dept Social Med, Rua Barcelos 2600-414, BR-90035003 Porto A UFRGS Rua Barcelos 2600-414 Porto Alegre RS Brazil BR-90035003 BC
Citazione:
M.I. Schmidt et al., "Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study", LANCET, 353(9165), 1999, pp. 1649-1652

Abstract

Background Type 2 diabetes mellitus and atherosclerotic cardiovascular disease have common antecedents. Since markers of inflammation predict coronary heart disease and are raised in patients with type 2 diabetes, we investigated whether they predict whether people will develop type 2 diabetes. Methods 12 330 men and women, aged 45-64 years, were followed up for a mean of 7 years. We analysed the association between different markers of acute inflammation and subsequent diagnosis of diabetes. In a subgroup of 610 individuals selected originally for an unrelated atherosclerosis case-control study, we also investigated diabetes associations with total sialic acid and orosomucoid, haptoglobin, and alpha(1)-antitrypsin. Findings 1335 individuals had a new diagnosis of diabetes. Adjusted odds ratios for developing diabetes for quartile extremes were 1.9 (95% CI 1.6-2.3) for raised white-cell count, 1.3 (1.0-1.5) for low serum albumin, and 1.2 (1.0-1.5) for raised fibrinogen. In the subgroup analysis, individuals with concentrations of orosomucoid and sialic acid of more than the median had odds ratios of 7.9 (2.6-23.7) and 3.7 (1.4-9.8), respectively. Adjustmentfor body-mass index and waist-to-hip ratio lessened the associations; those for white-cell count (1.5 [1.3-1.8]), orosomucoid (7.1 [2.1-23.7]), and sialic acid (2.8 [1.0-8.1]) remained significant. Interpretation Markers of inflammation are associated with the developmentof diabetes in middle-aged adults. Although autoimmunity may partly explain these associations, they probably reflect the pathogenesis of type 2 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:02:16