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Titolo:
The dopamine D-2, but not D-3 or D-4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice
Autore:
Ralph, RJ; Varty, GB; Kelly, MA; Wang, YM; Caron, MG; Rubinstein, M; Grandy, DK; Low, MJ; Geyer, MA;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rmacol, Portland, OR 97201 USA Duke Univ, Med Ctr, Dept Cell Biol, Howard Hughes Med Inst Labs, Durham, NC Duke Univ Durham NC USA 27710 ol, Howard Hughes Med Inst Labs, Durham, NC Univ Buenos Aires, Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet Univ Buenos Aires Buenos Aires DF Argentina RA-1428 nst Invest Ingn Genet Univ Buenos Aires, Dept Biol, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1428 Aires, DF, Argentina
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 19, anno: 1999,
pagine: 4627 - 4633
SICI:
0270-6474(19990601)19:11<4627:TDDBND>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; SCHIZOPHRENIC-PATIENTS; DEFICIENT MICE; ANIMAL-MODEL; RAT STRAINS; HABITUATION; APOMORPHINE; AGONIST; NEUROLEPTICS; STIMULATION;
Keywords:
prepulse inhibition; startle; mice; dopamine receptors; genetics; amphetamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Geyer, MA Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA UnivCalif San Diego La Jolla CA USA 92093 Jolla, CA 92093 USA
Citazione:
R.J. Ralph et al., "The dopamine D-2, but not D-3 or D-4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice", J NEUROSC, 19(11), 1999, pp. 4627-4633

Abstract

Brain dopamine (DA) systems are involved in the modulation of the sensorimotor gating phenomenon known as prepulse inhibition (PPI). The class of D2-like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the control of PPI via studies of DA agonists and antagonists in rats. Nevertheless, the functional relevance of each receptor subtype remains unclear because these ligands are not specific. To determine the relevance of each receptor subtype, we used genetically altered strains of "knock-out" mice lacking the DA D2, D3, or D4 receptors. We tested the effects of each knock-out on both the phenotypic expression of PPI and the disruption of PPI produced by the indirect DA agonist d-amphetamine (AMPH). No phenotypic differences in PPI were observed at baseline. AMPH significantlydisrupted PPI in the D2 (+/+) mice but had no effect in the D2 (-/-) mice. After AMPH treatment, both DA D3 and D4 receptor (+/+) and (-/-) mice had significant disruptions in PPI. These findings indicate that the AMPH-induced disruption of PPI is mediated via the DA D2 receptor and not the D3 or D4 receptor subtypes. Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:37:50