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Titolo:
Long-term treatment of cervical dystonia with botulinum toxin A: efficacy,safety, and antibody frequency
Autore:
Kessler, KR; Skutta, M; Benecke, R;
Indirizzi:
Univ Rostock, Neurol Klin & Poliklin, D-18147 Rostock, Germany Univ Rostock Rostock Germany D-18147 Poliklin, D-18147 Rostock, Germany Univ Dusseldorf, Neurol Klin & Poliklin, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Free Univ Berlin, Dept Neurol, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 pt Neurol, D-1000 Berlin, Germany Univ Freiburg, Dept Neurol, D-7800 Freiburg, Germany Univ Freiburg Freiburg Germany D-7800 t Neurol, D-7800 Freiburg, Germany Innsbruck Univ, Dept Neurol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 eurol, A-6020 Innsbruck, Austria Univ Kiel, Dept Neurol, D-24098 Kiel, Germany Univ Kiel Kiel Germany D-24098 Kiel, Dept Neurol, D-24098 Kiel, Germany Univ Marburg, Dept Neurol, D-35032 Marburg, Germany Univ Marburg MarburgGermany D-35032 pt Neurol, D-35032 Marburg, Germany Univ Munich, Klinikum Grosshadern, Dept Neurol, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 Dept Neurol, D-80539 Munich, Germany Tech Univ Munich, Dept Neurol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 pt Neurol, D-8000 Munich, Germany Univ Freiburg, Dept Med Biometry & Stat, D-7800 Freiburg, Germany Univ Freiburg Freiburg Germany D-7800 y & Stat, D-7800 Freiburg, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 4, volume: 246, anno: 1999,
pagine: 265 - 274
SICI:
0340-5354(199904)246:4<265:LTOCDW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPASMODIC TORTICOLLIS; DOUBLE-BLIND; NEUROMUSCULAR-TRANSMISSION; LOCAL INJECTIONS; CONTROLLED TRIAL; FOLLOW-UP; A TOXIN; RESISTANCE; THERAPY;
Keywords:
cervical dystonia; torticollis; botulinum toxin; prospective follow-up study; antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Benecke, R UnivGermanyk, Neurol Klin & Poliklin, Gehlsheimer Str 20, D-18147 Rostock, Univ Rostock Gehlsheimer Str 20 Rostock Germany D-18147 stock,
Citazione:
K.R. Kessler et al., "Long-term treatment of cervical dystonia with botulinum toxin A: efficacy,safety, and antibody frequency", J NEUROL, 246(4), 1999, pp. 265-274

Abstract

Data from 616 patients suffering from idiopathic cervical dystonia were analyzed to determine the efficacy and safety of treatment with botulinum neurotoxin type A (BoNT/A). Since the specific purpose of this study was to determine the long-term effects of this treatment, the analysis focused specifically on the patients (n = 303) having received six or more injections. Statistical analysis of a standardized documentation showed sustained significant benefit as measured by a disease severity score independent of the type of cervical dystonia. Furthermore, pronounced individual differences were found in response to this treatment although initial clinical scores and doses of BoNT/A were similar. There was no indication of previously unknownadverse events, the only risk being the development of serum antibodies against the toxin. As in previous studies on short-term effects of BoNT/A treatment, the most frequent adverse event was dysphagia, which occurred on average 9.7 days after injection and lasted on average 3.5 weeks. While secondary nonresponse was seen in approx. 5% of patients, antibody tests revealed neutralizing serum antibodies in only 2%. On the basis of the present data, therapy of cervical dystonia with BoNT/A seems to be safe and yields good stable results even after 5 years of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:46:57