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Titolo:
Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system
Autore:
Vedder, H; Anthes, N; Stumm, G; Wurz, C; Behl, C; Krieg, JC;
Indirizzi:
Univ Marburg, Dept Psychiat & Psychotherapy, D-35033 Marburg, Germany UnivMarburg Marburg Germany D-35033 hotherapy, D-35033 Marburg, Germany Univ Marburg, Dept Neuropathol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 uropathol, D-35033 Marburg, Germany Max Planck Inst Psychiat, D-8000 Munich, Germany Max Planck Inst PsychiatMunich Germany D-8000 t, D-8000 Munich, Germany
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 6, volume: 72, anno: 1999,
pagine: 2531 - 2538
SICI:
0022-3042(199906)72:6<2531:EHRLPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE STRESS; REPLACEMENT THERAPY; ALZHEIMERS-DISEASE; FREE-RADICALS; IN-VITRO; BRAIN; NEURONS; INJURY; RISK; RAT;
Keywords:
neuron; brain; steroid; neuroprotection; estradiol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Vedder, H Univ Marburg, Dept Psychiat & Psychotherapy, Rudolf Bultmann Str8, D-35033 Univ Marburg Rudolf Bultmann Str 8 Marburg Germany D-35033 5033
Citazione:
H. Vedder et al., "Estrogen hormones reduce lipid peroxidation in cells and tissues of the central nervous system", J NEUROCHEM, 72(6), 1999, pp. 2531-2538

Abstract

Effects of estrogen hormones on lipid peroxidation (LPO) were examined in rat brain homogenates (RBHs), hippocampal HT 22 cells, rat primary neocortical cultures, and human brain homogenates (HBHs). Dose-response curves indicated half-maximal effective concentrations (EC50) of 5.5 and 5.6 mM for iron-induced LPO in RBHs and HT 22 homogenates. Incubation of living rat primary neocortical cultures with iron resulted in an EC50 of 0.5 mM, whereas culture homogenates showed an EC50 of 1.2 mM. Estrogen hormones reduced LPO in all systems: In RBHs, estrone inhibited iron-induced LPO to 74.1 +/- 5.8% of control levels (17 beta-estradiol: 71.3 +/- 0.1%) at a concentration of 10 mu M. In hippocampal HT 22 cell homogenates, levels of LPO were reduced to 74.8 +/- 5.5% by estrone and to 47.8 +/- 6.2% by 17 beta-estradiol. Inliving neocortical cultures, 17 beta-estradiol decreased iron-induced LPO to 79.2 +/- 4.8% and increased the survival of cultured neuronal cells. Of the other steroid compounds tested (corticosterone, progesterone, testosterone), only progesterone decreased LPO in HT 22 cell homogenates. In HBHs, LPO was dose-dependently increased by iron concentrations from 2.7 to 6.0 mM. Incubation with estrogens resulted in a dose-dependent inhibition of LPO to 53.8 +/- 8.6% with 10 mu M 17 beta-estradiol, whereas estrone failed to affect iron-induced LPO to a significant extent. Nonestrogenic steroids, including hydrocortisol, did not show significant effects on LPO in HBHs.

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Documento generato il 05/07/20 alle ore 07:09:09