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Titolo:
Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons
Autore:
Schwarzschild, MA; Cole, RL; Meyers, MA; Hyman, SE;
Indirizzi:
MassachusettsAGen Hosp, Dept Neurol, Lab Mol & Dev Neurosci, Charlestown, M Massachusetts Gen Hosp Charlestown MA USA & Dev Neurosci, Charlestown, M Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA Massachusetts Gen Hosp Charlestown MA USA Psychiat, Charlestown, MA USA Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Neurosci Program, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 6, volume: 72, anno: 1999,
pagine: 2248 - 2255
SICI:
0022-3042(199906)72:6<2248:CCDOSA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NMDA RECEPTOR ACTIVATION; CENTRAL-NERVOUS-SYSTEM; PROTEIN-KINASE-C; GROWTH-FACTOR; NITRIC-OXIDE; CELL-DEATH; HIPPOCAMPAL-NEURONS; CORTICAL-NEURONS; GENE-EXPRESSION;
Keywords:
glutamate; N-methyl-D-aspartate; c-Jun N-terminal kinase; extracellular-regulated kinase; calcium; sodium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzschild, MA MolSAeurobiol Lab, CNY-6616,MGH-E,Bldg 149,13th St, Charlestown, MA 02129 U Mol Neurobiol Lab CNY-6616,MGH-E,Bldg 149,13th St Charlestown MA USA 02129
Citazione:
M.A. Schwarzschild et al., "Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons", J NEUROCHEM, 72(6), 1999, pp. 2248-2255

Abstract

Stress-activated protein kinase (SAPK) and extracellular signal-regulated kinase (ERK), both members of the mitogen-activated protein kinase (MAPK) family, may in some circumstances serve opposing functions with respect to cell survival. However, SAPK and ERK can also be coordinately activated in neurons in response to glutamate stimulation of NMDA receptors. To explore the mechanisms of these MAPK activations, we compared the ionic mechanisms mediating SAPK and ERK activations by glutamate. In primary cultures of striatal neurons, glutamatergic activation of ERK and one of its transcription factor targets, CREB, showed a calcium dependence typical of NMDA receptor-mediated responses. In contrast, extracellular calcium was not required forglutamatergic, NMDA receptor-mediated activation of SAPK and phosphorylation of its substrate, c-Jun. Increasing extracellular calcium enhanced ERK activation but reversed SAPK activation, further distinguishing the calcium dependencies of these two NMDA receptor-mediated effects. Finally, reducingextracellular sodium prevented the glutamatergic activation of SAPK but only partially blocked that of ERK. These contrasting ionic dependencies suggest a mechanism by which NMDA receptor activation may, under distinct conditions, differentially regulate neuronal MAPKs and their divergent functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:04:52