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Titolo:
Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women
Autore:
Sung, BH; Ching, M; Izzo, JL; Dandona, P; Wilson, MF;
Indirizzi:
Millard Fillmore Hosp, Dept Med, Buffalo, NY 14209 USA Millard Fillmore Hosp Buffalo NY USA 14209 ept Med, Buffalo, NY 14209 USA SUNY, Dept Med, Buffalo, NY USA SUNY Buffalo NY USASUNY, Dept Med, Buffalo, NY USA
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 17, anno: 1999,
pagine: 523 - 528
SICI:
0263-6352(199904)17:4<523:EIANVI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENTAL STRESS; PLASMA-LIPOPROTEINS; CORONARY-ARTERIES; RESPONSES; 17-BETA-ESTRADIOL; PREMENOPAUSAL; REPLACEMENT; CHOLESTEROL; MENOPAUSAL;
Keywords:
estrogen; menopause; vasoreactivity; norepinephrine; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sung, BH Millard Fillmore Hosp, Dept Med, 3 Gates Circle, Buffalo, NY 14209 USA Millard Fillmore Hosp 3 Gates Circle Buffalo NY USA 14209 209 USA
Citazione:
B.H. Sung et al., "Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women", J HYPERTENS, 17(4), 1999, pp. 523-528

Abstract

Objective An exaggerated blood pressure response to mental stress in postmenopausal women has been reported but the underlying mechanism is not clear, In the present study, we examined the role of estrogen in the blood pressure response to mental stress. Subjects and methods Hemodynamic responses to mental stress and constrictor responses to norepinephrine were compared in 18 premenopausal (mean +/- SD age 33 +/- 5 years), 22 postmenopausal women (62 +/- 7 years) and 13 postmenopausal women with estrogen replacement therapy (58 +/- 8 years). Premarin was infused in 10 postmenopausal women to determine whether estrogen attenuates norepinephrine-induced vasoconstriction. The hemodynamic responses to a standard mental arithmetic test were measured. Norepinephrine (12.5, 25, 50, 100 ng/min) was infused at 0.5 ml/min for 5 min via the dorsal hand vein. Norepinephrine (100 ng/min) combined with premarin (200 mu g/min) wasinfused into the dorsal hand vein of postmenopausal women. Changes in venous diameter were measured by ultrasonography using a 7.5 MHz transducer. Results All study subjects were healthy, normotensive and had normal lipidprofiles, The postmenopausal women showed a significantly greater blood pressure response to the mental arithmetic test than the premenopausal women or those taking estrogen replacement therapy (P < 0.01). Norepinephrine induced significant dose-dependent vasoconstriction in all three groups (P < 0.001), The postmenopausal women showed significantly greater constriction in response to norepinephrine than the premenopausal women and those taking estrogen replacement therapy (P = 0.02). Premarin significantly attenuated the norepinephrine-induced vasoconstriction in the postmenopausal women (P < 0.001). Conclusion Healthy, normotensive postmenopausal women showed an exaggerated blood pressure response to mental stress. An increased vasoconstriction in response to norepinephrine and loss of estrogen-mediated vasodilation maycontribute to the increased blood pressure response to stress in postmenopausal women without estrogen replacement therapy. J Hypertens 1999, 17:523-528 (C) Lippincott Williams & Wilkins.

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Documento generato il 23/10/20 alle ore 11:38:39