Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats
Autore:
Fazan, R; da Silva, VJD; Ballejo, G; Salgado, HC;
Indirizzi:
UnivPreto,aulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 RibeiraoUniv Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCR-14049900 Ribeirao Sch Med Triangulo Med, Dept Biol Sci, Uberaba, MG, Brazil Sch Med Triangulo Med Uberaba MG Brazil pt Biol Sci, Uberaba, MG, Brazil UnivoSao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeira Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCBR-14049900 Ribeira
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 17, anno: 1999,
pagine: 489 - 495
SICI:
0263-6352(199904)17:4<489:PSOAPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; AUTONOMIC NEUROPATHY; RATE-VARIABILITY; CONSCIOUS RATS; CARDIOVASCULAR VARIABILITY; SYMPATHETIC DENERVATION; NERVOUS DYSFUNCTION; CRITICAL-APPRAISAL; FLUCTUATIONS; OSCILLATIONS;
Keywords:
streptozotocin; spectral analysis; diabetes; rats; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Salgado, HC UnivPreto,aulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCibeirao
Citazione:
R. Fazan et al., "Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats", J HYPERTENS, 17(4), 1999, pp. 489-495

Abstract

Background Chronic diabetes is associated with alterations in autonomic modulation of the cardiovascular system. Although the rat has been used extensively in studies of experimental diabetes, there have been no reports on the changes in autonomic modulation of the cardiovascular function in chronic diabetic rats. Objective To examine chronic diabetic rats to determine the autonomic modulation of arterial pressure and heart rate variabilities in the time and frequency domain. Materials and methods Diabetes was induced in rats by a single injection of streptozotocin, and 30 min of pulsatile arterial pressure was recorded inconscious rats, 5, 10-20 days and 12-18 weeks after the streptozotocin injection. Control rats were injected with vehicle. Beat-by-beat systolic arterial pressure and heart rate were obtained from pulsatile pressure. The spectral density powers of systolic arterial pressure and heart rate were calculated using fast Fourier transformation, and integrated in low- (0.015-0.25 Hz), mid- (0.25-0.75 Hz) and high- (0.75-3.0 Hz) frequency bands. The standard deviations of systolic arterial pressure and heart rate were also calculated. Results Basal systolic arterial pressure and heart rate were reduced in diabetic animals studied 10-20 days and 12-18 weeks after the streptozotocin injection. The standard deviations of systolic arterial pressure and heart rate were also reduced in the chronically diabetic animals. Diabetes reduced low- and mid-frequency variability but not the high-frequency variabilityof systolic arterial pressure. The low-frequency variability, but not the midfrequency variability, of the heart rate was also reduced, while the high-frequency variability of the heart rate was reduced in the more chronically diabetic rats. Conclusion Our findings that the mid-frequency band variability of arterial pressure was reduced in diabetic patients suggest that sympathetic modulation of the cardiovascular system is impaired, corroborating other studies in such patients using this and other approaches. J Hypertens 1999, 17:489-495 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:51:23