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Titolo:
MATRIX COLLAGEN TYPE AND PORE-SIZE INFLUENCE BEHAVIOR OF SEEDED CANINE CHONDROCYTES
Autore:
NEHRER S; BREINAN HA; RAMAPPA A; YOUNG G; SHORTKROFF S; LOUIE LK; SLEDGE CB; YANNAS IV; SPECTOR M;
Indirizzi:
HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DEPT ORTHOPED SURG,75 FRANCIS ST BOSTON MA 02115 MIT,DEPT HLTH SCI & TECHNOL CAMBRIDGE MA 02139 MIT,DEPT ENGN MECH CAMBRIDGE MA 02139 UNIV VIENNA,DEPT ORTHOPED SURG VIENNA AUSTRIA BROCKTON W ROXBURY VET AFFAIRS MED CTR W ROXBURY MA 00000
Titolo Testata:
Biomaterials
fascicolo: 11, volume: 18, anno: 1997,
pagine: 769 - 776
SICI:
0142-9612(1997)18:11<769:MCTAPI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR-MATRIX; ARTICULAR CHONDROCYTES; CELL-SHAPE; CARTILAGE; PHENOTYPE; INVITRO; SKIN;
Keywords:
CARTILAGE REPAIR; TISSUE ENGINEERING; COLLAGEN MATRICES; CHONDROCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Nehrer et al., "MATRIX COLLAGEN TYPE AND PORE-SIZE INFLUENCE BEHAVIOR OF SEEDED CANINE CHONDROCYTES", Biomaterials, 18(11), 1997, pp. 769-776

Abstract

This study directly compared the behaviour of chondrocytes in porous matrices comprising different collagen types and different pore diameters. There was a dramatic difference in the morphology of the cells inthe type I and type II collagen matrices. The cells in the type II collagen matrix retained their chondrocytic morphology and synthesized glycosaminoglycans, while in the type I matrix the chondrocytes displayed a fibroblastic morphology with less biosynthetic activity than those in the type It. Small pore diameter affected morphology initially inthe type I matrices and showed a higher increase of DNA content, but with time the cells lost the chondrocytic morphology. Our results demonstrate the marked influence of collagen type and pore characteristicson the phenotypic expression of seeded chondrocytes. (C) 1997 Elsevier Science Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:18:10