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Titolo:
Differences in the urinary excretion of 6-beta-hydroxycortisol/cortisol between Asian and Caucasian women
Autore:
Lin, YX; Anderson, GD; Kantor, E; Ojemann, LM; Wilensky, AJ;
Indirizzi:
Univ Washington, Dept Pharm, Sch Pharm, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 rm, Sch Pharm, Seattle, WA 98195 USA Univ Washington, Sch Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 gton, Sch Med, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 6, volume: 39, anno: 1999,
pagine: 578 - 582
SICI:
0091-2700(199906)39:6<578:DITUEO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P450 3A4 ACTIVITY; MENSTRUAL-CYCLE; CYP3A ACTIVITY; PREDNISOLONE DISPOSITION; LIVER-MICROSOMES; ENZYME-INDUCTION; PHARMACOKINETICS; GENDER; PHARMACODYNAMICS; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, YX Univ Washington, Dept Pharm, Sch Pharm, Box 357630, Seattle, WA 98195 USA Univ Washington Box 357630 Seattle WA USA 98195 ttle, WA 98195 USA
Citazione:
Y.X. Lin et al., "Differences in the urinary excretion of 6-beta-hydroxycortisol/cortisol between Asian and Caucasian women", J CLIN PHAR, 39(6), 1999, pp. 578-582

Abstract

The urinary ratio of 6-beta-hydroxycortisol/cortisol has been used as a noninvasive probe for human cytochrome P450 3A4 isoforms (CYP3A4). Ethnic-related differences in the ratio have not been evaluated. The aim of this study was to determine if there are differences in the ratio between Asian and Caucasian women over a menstrual cycle. First-morning urine samples were collected every other day starting from the second day of menstruation far a complete menstrual cycle From 25 Asians and 26 Caucasian women who were 18 to 40 years old, healthy nonsmoking, and alcohol and drug free, including oral contraceptives. Urine concentrations of 6-beta-hydroxycortisol and cortisol were measured by high-pressure liquid chromatography (HPLC). For statistical analysis, three phases of the menstrual cycle were evaluated menstruation (days 1-4), follicular or postmenstruation (days 6-10), and the luteal phase (days 21-24) based on the average menstrual cycle (28 days). Statistical analysis was performed by an independent sample t-test using the Bonferroni correction far repeated measures. Large intersubject and intrasubject variations of the 6-beta-hydroxycortisol/cortisol ratios were absented during the menstrual cycles in bath ethnic groups. Asian women had a statistically significant lower ratio than Caucasian women did for all three phasesof the menstrual cycle: 2.2 +/- 1.1 versus 5.1 +/- 3.5, 2.1 +/- 1.1 versus6.0 +/- 4.9, and 2.8 +/- 1.6 versus 5.6 +/- 3.0 for the menstruation, follicular, and luteal phases, respectively. The two- to threefold lower 6-beta-hydroxycortisol/cortisol ratios in Asian women suggest that Asian women may have a lower CYP3A activity compared with Caucasian women. Differences inethnicity may mask potential gender-related effects if ethnic background is not evaluated as a contributing factor. (C) 1999 the American College of Clinical Pharmacology.

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Documento generato il 27/01/20 alle ore 07:43:54