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Titolo:
Abnormal glycosylation of IgG as a clinical parameter in patients with rheumatoid arthritis: Its constitutional analysis by HPLC
Autore:
Mukofujiwara, Y; Otsuka, T; Waguri, Y; Matsui, N; Asai, K; Kato, T; Araki, H; Tsukamoto, Y; Takahashi, N;
Indirizzi:
Nagoya8601, Univ, Sch Med, Dept Orthoped Surg, Mizuho Ku, Nagoya, Aichi 467 Nagoya City Univ Nagoya Aichi Japan 4678601 Mizuho Ku, Nagoya, Aichi 467 Nagoya78601,Univ, Sch Med, Dept Bioregulat Res, Mizuho Ku, Nagoya, Aichi 46 Nagoya City Univ Nagoya Aichi Japan 4678601 , Mizuho Ku, Nagoya, Aichi 46 Nakano Vinegar Co Ltd, Glycolab, Nakano Cent Res Inst, Handa 4750873, Japan Nakano Vinegar Co Ltd Handa Japan 4750873 Res Inst, Handa 4750873, Japan
Titolo Testata:
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
fascicolo: 3, volume: 25, anno: 1998,
pagine: 131 - 142
SICI:
0912-0009(1998)25:3<131:AGOIAA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-G; GALACTOSYLTRANSFERASE; OLIGOSACCHARIDES; GALACTOSE; DISEASE; PROTEIN; SERUM;
Keywords:
IgG; glycosylation; rheumatoid arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Mukofujiwara, Y Nagoya8601, Univ, Sch Med, Dept Orthoped Surg, Mizuho Ku, Nagoya, Aichi 467 Nagoya City Univ Nagoya Aichi Japan 4678601 ya, Aichi 467
Citazione:
Y. Mukofujiwara et al., "Abnormal glycosylation of IgG as a clinical parameter in patients with rheumatoid arthritis: Its constitutional analysis by HPLC", J CL BIOC N, 25(3), 1998, pp. 131-142

Abstract

To determine the abnormal glycosylation patterns of IgG in patients with rheumatoid arthritis (RA), we analyzed these oligosaccharide profiles using a recently established high-performance liquid chromatography (HPLC) method. Oligosaccharides of IgG proteins purified from sera of RA patients were labeled with a fluorescent reagent, 2-aminopyridine. The oligosaccharide derivatives were separated into 12 peaks by HPLC, and compared with those of age-matched controls. Serum IgG from patients with RA (RA-IgG) contained a higher content of oligosaccharides with bisecting GlcNAc than normal IgG, which was accompanied by an increase in the glycosylation of the bisected oligosaccharides. The ratio of the glycosylation of bisected to nonbisected oligosaccharides correlated with RA disease activity as well as with its clinical markers. This ratio reflecting the balance of glycosylation between bisected and nonbisected oligosaccharides may be a useful clinical parameter to monitor RA activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:03:36