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Titolo:
No difference between platelet serotonin - 5-HT2A receptors from children with and without ADHD
Autore:
Pornnoppadol, C; Friesen, DS; Haussler, TS; Glaser, PEA; Todd, RD;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 9, anno: 1999,
pagine: 27 - 33
SICI:
1044-5463(1999)9:1<27:NDBPS->2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; HUMAN BLOOD-PLATELETS; AGE-RELATED-CHANGES; IMPULSIVE AGGRESSION; SUICIDAL-BEHAVIOR; FRONTAL-CORTEX; H-3 PAROXETINE; WHOLE-BLOOD; BINDING; DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pornnoppadol, C Washington Univ, Sch Med, Dept Psychiat, Campus Box 8134,4940 Childrens Pl, Washington Univ Campus Box 8134,4940 Childrens Pl St Louis MO USA 63110
Citazione:
C. Pornnoppadol et al., "No difference between platelet serotonin - 5-HT2A receptors from children with and without ADHD", J CH AD PSY, 9(1), 1999, pp. 27-33

Abstract

To further investigate the possible function of the serotonergic system inthe pathophysiology of attention deficit hyperactivity disorder (ADHD), platelet serotonin 5-HT2A receptors were characterized for 19 ADHD children and 17 age-matched control subjects. Subjects were evaluated using the Diagnostic Interview for Children and Adolescents (DICA-R-C)-DSM IV and the Children's Depression Inventory. An aggressive subgroup was also determined by the presence of two or more positive aggressive symptoms on either subjects' or parents' reports. Platelets were isolated from venous blood and 5-HT2Areceptor number, and affinity was determined using I-125-LSD binding. There was no difference in platelet 5-HT2A receptor binding characteristics between the two groups. The results from this pilot study suggest a limited function of 5-HT2A receptors in the pathophysiology of ADHD and extend the findings of other previous negative studies of the peripheral serotonergic system in ADHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:14:33