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Titolo:
Primary cutaneous marginal center lymphoma - complete remission induced byinterferon alpha 2a
Autore:
Wollina, U; Hahnfeld, S; Kosmehl, H;
Indirizzi:
Univ Jena, Dept Dermatol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Dept Dermatol, D-07740 Jena, Germany Oncol Outpatient Unit Ruffert Krombholz Hahnfeld, D-07743 Jena, Germany Oncol Outpatient Unit Ruffert Krombholz Hahnfeld Jena Germany D-07743 ny Univ Jena, Inst Pathol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Jena, Inst Pathol, D-07740 Jena, Germany
Titolo Testata:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
fascicolo: 5, volume: 125, anno: 1999,
pagine: 305 - 308
SICI:
0171-5216(199905)125:5<305:PCMCL->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL LYMPHOMA; MANTLE ZONE; T-CELL; ENTITY; SKIN; CLASSIFICATION; SECTIONS; MALT;
Keywords:
primary cutaneous B-cell lymphoma; marginal zone lymphoma; interferon alpha 2a;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wollina, U Univ Jena, Dept Dermatol, Erfurter Str 35, D-07740 Jena, Germany Univ Jena Erfurter Str 35 Jena Germany D-07740 0 Jena, Germany
Citazione:
U. Wollina et al., "Primary cutaneous marginal center lymphoma - complete remission induced byinterferon alpha 2a", J CANC RES, 125(5), 1999, pp. 305-308

Abstract

Marginal zone lymphoma (MZL) is a distinct entity among B-cell lymphomas. We report on a 53-year-old woman who developed disseminated primary cutaneous MZL with secondary lymph node involvement and perinodular spreading. Thetumor cell phenotype was characterized as CD20/CD79a/kappa/lambda+/ bcl-2-positive, CD3/5/15/39/bcl-1-negative. Ki-67 was expressed by 20-35% of tumor cells. There was no evidence of systemic (including bone marrow) involvement. The diagnosis of MZL with plasmacellular differentiation (Stage IVa) was made. The patient was treated with interferon alpha 2a injected s.c. at 9 x 10(6) U 3 days a week for 1 year. During this time the skin lesions completely disappeared. No evidence of lymph node or extracutaneous disease was found. The patient remains in complete remission. Side effects were only of grade I (WHO); the Karnovsky index was 90%. As shown for other types of primary cutaneous B-cell lymphoma, prolonged interferon alpha monotherapy may be effective in controlling the disease and/or inducing complete remission in MZL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:31:29