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Titolo:
Altered [H-3]imipramine and 5-HT2 but not [H-3]paroxetine binding sites inplatelets from depressed patients
Autore:
Rosel, P; Arranz, B; Vallejo, J; Alvarez, P; Menchon, JM; Palencia, T; Navarro, MA;
Indirizzi:
Hosp Llobregat, Hormone Unit, Dept Biochem, Barcelona, Spain Hosp Llobregat Barcelona Spain one Unit, Dept Biochem, Barcelona, Spain Hosp Princeps Espanya, Dept Psychiat, Barcelona, Spain Hosp Princeps Espanya Barcelona Spain , Dept Psychiat, Barcelona, Spain CASM, Barcelona, Spain CASM Barcelona SpainCASM, Barcelona, Spain
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1-3, volume: 52, anno: 1999,
pagine: 225 - 233
SICI:
0165-0327(199901/03)52:1-3<225:A[A5BN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; ADRENERGIC-RECEPTOR BINDING; SUICIDE VICTIMS; H-3-IMIPRAMINE BINDING; SEROTONIN TRANSPORTER; TRITIATED IMIPRAMINE; MAJOR DEPRESSION; HEALTHY CONTROLS; BLOOD-PLATELETS; FRONTAL-CORTEX;
Keywords:
[H-3]imipramine; [H-3]paroxetine; [H-3]ketanserin; 5HT2; endogenous depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rosel, P Hospainobregat, Hormone Unit, Dept Biochem, Feixa Llarga S-N, Barcelona, Sp Hosp Llobregat Feixa Llarga S-N Barcelona Spain , Barcelona, Sp
Citazione:
P. Rosel et al., "Altered [H-3]imipramine and 5-HT2 but not [H-3]paroxetine binding sites inplatelets from depressed patients", J AFFECT D, 52(1-3), 1999, pp. 225-233

Abstract

Background: Serotonergic system alterations were studied in 51 depressed patients classified according to DSM-III-R criteria for major depression with melancholia compared to 31 healthy controls. Method: [H-3]Imipramine and [H-3]paroxetine binding sites and the 5HT2 receptor were simultaneously determined in blood platelet membranes. Results: A significantly lower maximumbinding in [H-3]imipramine binding was observed in depressed patients compared to controls (1134 +/- 74 vs. 1712 +/- 106 fmol/mg protein, P < 0.0001)without changes in the equilibrium dissociation constant (1.10 +/- 0.05 vs. 1.25 +/- 0.09 nM). [H-3]Paroxetine binding did not differ between the twogroups (B-max, 1441 +/- 55 vs. 1280 +/- 81 fmol/mg protein; K-d, 0.060 +/-0.002 vs. 0.062 +/- 0.002 nM). The K-d value of 5HT2 binding was lower in depressed patients than controls (0.95 +/- 0.04 vs. 1.15 +/- 0.09 nM, P < 0.039) without changes in maximum binding (140 +/- 11 vs. 127 +/- 14 fmol/mgprotein). Conclusions: Taken together, these results suggest that [H-3]imipramine and 5HT2 receptors may be good biological markers for serotonergic dysfunction in depressive disorders. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 10:19:47