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Titolo:
Importance of pharmacological and physicochemical properties for toleranceof antimuscarinic drugs in the treatment of detrusor instability and detrusor hyperreflexia - Chances for improvement of therapy
Autore:
Schwantes, U; Topfmeier, P;
Indirizzi:
Dr R Pfleger GMBH, Dept Med Sci & Clin Res, D-96045 Bamberg, Germany Dr R Pfleger GMBH Bamberg Germany D-96045 Res, D-96045 Bamberg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
fascicolo: 5, volume: 37, anno: 1999,
pagine: 209 - 218
SICI:
0946-1965(199905)37:5<209:IOPAPP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVESICAL OXYBUTYNIN CHLORIDE; TROSPIUM CHLORIDE; RECEPTOR SUBTYPES; URGE INCONTINENCE; MUSCARINIC RECEPTORS; NEUROGENIC BLADDER; HUMAN-PLASMA; DOUBLE-BLIND; TRIAL; TOLTERODINE;
Keywords:
antimuscarinic drugs; tolerance; detrusor instability; detrusor hyperreflexia; oral administration; dermal delivery system; intravesical instillation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Schwantes, U Dr R Pfleger GMBH, Dept Med Sci & Clin Res, D-96045 Bamberg, Germany Dr R Pfleger GMBH Bamberg Germany D-96045 Bamberg, Germany
Citazione:
U. Schwantes e P. Topfmeier, "Importance of pharmacological and physicochemical properties for toleranceof antimuscarinic drugs in the treatment of detrusor instability and detrusor hyperreflexia - Chances for improvement of therapy", INT J CL PH, 37(5), 1999, pp. 209-218

Abstract

Background: Antimuscarinic side-effects are relatively frequent problems in oral pharmacotherapy of detrusor instability and neurogenic dysfunction of the urinary bladder. Results of recent clinical trials demonstrate differences in tolerance between antimuscarinic drugs. It is the purpose of this paper to relate the available clinical data to the pharmacological and physicochemical properties of the different antimuscarinic drugs, in order to discuss the reasons for this enhanced tolerance and to make possible modes for improvement of antimuscarinic therapy plainly visible. Methods: Therefore, we reviewed the available literature using among others the computerizedlibrary systems Medline (National Library of Medicine, Bethesda, Maryland,USA) and Embase (Excerpta Medica, Amsterdam, the Netherlands). Differencesin tolerance of oral antimuscarinic drugs may result from muscarine-receptor selectivity, organ selectivity, and pharmacokinetic as well as physicochemical properties. While the roles of m-receptor and organ selectivity needmore detailed clarification, influences of differences in bioavailability and physicochemical properties on the tolerance of antimuscarinic drugs aremore sufficiently investigated. Results: Generally, tolerance as well as efficacy of antimuscarinic drugs seem to be a complex result of a combination of various pharmacological properties distinguishing the individual substances. The enhancement of tolerance of propiverine hydrochloride, tolterodine tartrate and trospium chloride compared to oxybutynin chloride seems to be reached by different modes, from which the molecular structure - propiverine and tolterodine are tertiary amines, trospium chloride possesses a quarternary ammonium structure - may be of great importance. First investigations with alternative transdermal and intravesical application routes show interesting possibilities for further improvement of antimuscarinic therapy in urological indications. Conclusion: In conclusion, from pharmacological and clinical data it becomes obvious that there are significant differencesbetween antimuscarinic drugs, which are of clinical relevance and include possible starting points for the development of new drugs and application forms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:58:03