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Titolo:
Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia
Autore:
Berk, M; Plein, H; Csizmadia, T;
Indirizzi:
Univ Witwatersrand, Dept Psychiat, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Univ Witwatersrand, Dept Expt & Clin Pharmacol, Johannesburg, South AfricaUniv Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 14, anno: 1999,
pagine: 119 - 122
SICI:
0268-1315(199903)14:2<119:SPGRAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; INTRACELLULAR CALCIUM; AFFECTIVE-DISORDERS; GENERATION; SEROTONIN; MODEL;
Keywords:
glutamate; platelet intracellular calcium response; receptor supersensitivity; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univuthtwatersrand, Sch Med, Dept Psychiat, 7 York Rd, ZA-2193 Parktown, So Univ Witwatersrand 7 York Rd Parktown South Africa ZA-2193 wn, So
Citazione:
M. Berk et al., "Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia", INT CLIN PS, 14(2), 1999, pp. 119-122

Abstract

Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia. The aim of this study was to examine the platelet intracellular calcium response to glutamate using spectroflourometry in 15 schizophrenic patients and 15 matched control individuals as an index of platelet glutamate receptor sensitivity. Patients with schizophrenia had significantly lower baseline intracellular calcium levels than matched control individuals (P = 0.03). The percentage response of the schizophrenic individuals to glutamate stimulation was significantly greater than control individuals (P < 0.001). These data suggest that platelet glutamate receptors may be supersensitive in schizophrenia. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia. Inr Clin Psychopharmacol 14:119-122 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:36:41