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Titolo:
Health effects of sulfur-related environmental air pollution. V. Lung structure
Autore:
Takenaka, S; Godleski, JJ; Heini, A; Karg, E; Kreyling, WG; Ritter, B; Schulz, H; Ziesenis, A; Heyder, J;
Indirizzi:
GSF,ermanyRes Ctr Environm & Hlth, Inst Inhalat Biol, D-85758 Neuherberg, G GSF Neuherberg Germany D-85758 Inst Inhalat Biol, D-85758 Neuherberg, G Harvard Univ, Sch Publ Hlth, Dept Environm Sci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Dept Environm Sci, Boston, MA 02115 USA
Titolo Testata:
INHALATION TOXICOLOGY
fascicolo: 5, volume: 11, anno: 1999,
pagine: 439 - 454
SICI:
0895-8378(199905)11:5<439:HEOSEA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH AMBIENT LEVELS; MUCOCILIARY CLEARANCE SYSTEM; ALVEOLATED DUCT STRUCTURE; LONG-TERM EXPOSURE; ACID MIST; RESPIRATORY BRONCHIOLITIS; INTERSTITIAL FIBROSIS; AEROSOL EXPOSURE; NITROGEN-DIOXIDE; PULMONARY ACINUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Takenaka, S GSF,herberg,s Ctr Environm & Hlth, Inst Inhalat Biol, POB 1129, D-85758 Neu GSF POB 1129 Neuherberg Germany D-85758 POB 1129, D-85758 Neu
Citazione:
S. Takenaka et al., "Health effects of sulfur-related environmental air pollution. V. Lung structure", INHAL TOXIC, 11(5), 1999, pp. 439-454

Abstract

The lungs of 8 male beagle dogs were examined morphologically and morphometrically after exposure for 13 mo to a respirable sulfur(IV) aerosol at a mass concentration of 1.53 mg m(-3) (16.5 h/day), and to an acidic sulfate aerosol carrying 15.2 mu mol m(-3) hydrogen ions into the lungs (6 h/day). An additional eight dogs served as unexposed controls. Standard morphometricanalyses of both the surface epithelia of the conducting airways and the alveolar region were performed. These analyses showed no difference between the exposure group and control group. However, there was a tendency to an increase in the volume density of bronchial glands in the exposure group. Five of eight exposed animals showed thickened ridges (knob-like structures) at the entrance to alveoli in the alveolar duct and alveolar sac. Transmission electron microscopy revealed that the thickening was mainly due to typeII cell proliferation. As the previous experiment using sulfite aerosol only showed no alterations in the proximal alveolar regions, the changes observed may be considered as effects of acidic sulfate aerosol alone or in combination with sulfite. These findings suggest that sulfur aerosols have thepotential to induce epithelial alterations in the proximal alveolar region, which is a primary target for air pollutants.

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Documento generato il 09/04/20 alle ore 06:47:14