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Titolo:
Health effects of sulfur-related environmental air pollution. II. Cellularand molecular parameters of injury
Autore:
Maier, KL; Beck-Speier, I; Dayal, N; Dirscherl, P; Griese, M; Heilmann, P; Hinze, H; Josten, M; Karg, E; Kreyling, WG; Lenz, AG; Leuschel, L; Meyer, B; Miaskowski, U; Reitmeir, P; Ruprecht, L; Schumann, G; Ziesenis, A; Heyder, J;
Indirizzi:
GSF,ermanyRes Ctr Environm & Hlth, Inst Inhalat Biol, D-85758 Neuherberg, G GSF Neuherberg Germany D-85758 Inst Inhalat Biol, D-85758 Neuherberg, G Univ Munich, Kinderpoliklin, Lung Res Grp, Munich, Germany Univ Munich Munich Germany inderpoliklin, Lung Res Grp, Munich, Germany GSF,58atl Res Ctr Environm & Hlth, Inst Med Informat & Hlth Serv Res, D-857 GSF Neuherberg Germany D-85758 Inst Med Informat & Hlth Serv Res, D-857
Titolo Testata:
INHALATION TOXICOLOGY
fascicolo: 5, volume: 11, anno: 1999,
pagine: 361 - 389
SICI:
0895-8378(199905)11:5<361:HEOSEA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ACID AEROSOLS; INTRACELLULAR PH; ALVEOLAR MACROPHAGES; ALKALINE-PHOSPHATASE; INHALED TC-99M-DTPA; HUMAN NEUTROPHILS; EPITHELIAL-CELLS; RAT LUNGS; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Maier, KL GSF,herberg,s Ctr Environm & Hlth, Inst Inhalat Biol, POB 1129, D-85758 Neu GSF POB 1129 Neuherberg Germany D-85758 , POB 1129, D-85758 Neu
Citazione:
K.L. Maier et al., "Health effects of sulfur-related environmental air pollution. II. Cellularand molecular parameters of injury", INHAL TOXIC, 11(5), 1999, pp. 361-389

Abstract

Recently, concern has been raised about effects related to environmental sulfur and/or acidic aerosols. To assess long-term effects on nonrespiratorylung function, 8 beagle dogs were exposed over a period of 13 mo for 16.5 h/day to a neutral sulfite aerosol at a sulfur(IV) concentration of 0.32 mgm(-3) and for 6 h/day to an acidic sulfate aerosol providing a hydrogen concentration of 15.2 mu mol m(-3) for inhalation. Prior to exposure the dogswere kept under clean air conditions for 16 mo to establish physiological baseline values for each animal. A second group of eight dogs (control) waskept for the entire study under clean air conditions. No clinical symptomswere identified that could be related to the combined exposure. Biochemical and cellular parameters were analyzed in sequential bronchoalveolar lavage (BAL) fluids. The permeability of the alveolocapillary membrane and diethylenetriaminepentaacetic acid (DTPA) clearance was not affected. Similarly,oxidant burden of the epithelial lining fluid evaluated by levels of oxidation products in the BAL fluid protein fraction remained unchanged. Both the lysosomal enzyme beta-N-acetylglucosaminidase and the alpha-1-AT were increased (p < .05). In contrast, the cytoplasmic marker lactate dehydrogenaseremained unchanged, indicating the absence of severe damages to epithelialcells or phagocytes. Various surfactant functions were not altered during exposure. Three animals showed elevated levels of the type II cell-associated alkaline phosphatase (AP), indicating a nonuniform response of type II cells. Significant correlations were found between AP and total BAL protein,but not between AP and lactate dehydrogenase, suggesting proliferation of alveolar type II cells. Absolute and relative cell counts in the BAL fluid were not influenced by exposure. Alveolar macrophages showed no alterationswith regard to their respiratory burst upon stimulation with opsonized zymosan. The percentage of alveolar macrophages capable of phagocytozing latexparticles was significantly decreased (p < .05), while the phagocytosis index was not altered. In view of the results of this and previous studies, we conclude that there is no synergism of effects of these two air pollutants on nonrespiratory lung functions. it is hypothesized that antagonistic effects of these air pollutants on phospholipase A(2)-dependent pathways account for compensatory physiological mechanisms. The results emphasize the complexity of health effects on lung functions in response to the complex mixture of air pollutants and disclose the precariousness in the risk assessment of air pollutants for humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:01:13