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Titolo:
Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial
Autore:
Parazzini, F; Di Cintio, E; Chatenoud, L; Moroni, S; Ardovino, I; Struzziero, E; Bracco, G; Pellegrini, A; Bertulessi, C; Busacca, M; Gruft, L; Ragni, G; Massobrio, M; Ansaldi, C; Trossarelli, GF; Eusebio, E; Troiano, L; Ricci, G;
Indirizzi:
Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 5, volume: 14, anno: 1999,
pagine: 1332 - 1334
SICI:
0268-1161(199905)14:5<1332:AOLONT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODALITIES;
Keywords:
clinical trial; endometriosis; infertility; laparoscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Parazzini, F Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
F. Parazzini et al., "Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial", HUM REPR, 14(5), 1999, pp. 1332-1334

Abstract

In order to analyse the efficacy of resection/ablation of mininal/mild endometriotic lesions for improving fertility, we conducted a randomized clinical trial. Eligible patients were women aged less than or equal to 36 yearswho were trying to conceive and had a laparoscopically confirmed diagnosisof minimal/mild endometriosis (stage I or II of the revised American Fertility Society classification) and otherwise unexplained infertility for greater than or equal to 2 years. Eligible women were randomly assigned to resection Or ablation of visible endometriosis (54 patients) or diagnostic laparoscopy only (47 patients). After laparoscopy women tried to conceive spontaneously for 1 year (follow-up period). A total of five women withdrew fromthe study: three for personal reasons, and two were lost to follow-up. Considering 51 women in the resection/ablation and 45 in the no-treatment group who ended the follow-up period, 12 (24%) in the resection/ablation group and 13 (29%) in the no treatment group conceived; the difference was not significant. Two spontaneous abortions were observed in the resection/ablation group and three in the no-treatment one. Thus the 1 year birth rate was 10 out of 51 women (19.6%) in the resection/ablation group and 10 out of 45 women (22.2%) in the no-treatment group. In conclusion, the results of thisstudy do not support the hypothesis that ablation of endometriotic lesionsmarkedly improves fertility rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:10:40