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Titolo:
How cells (might) sense microgravity
Autore:
Ingber, D;
Indirizzi:
Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp, Dept Surg, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 Hosp, Dept Surg, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
FASEB JOURNAL
, volume: 13, anno: 1999, supplemento:, S
pagine: S3 - S15
SICI:
0892-6638(1999)13:<S3:HC(SM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY ENDOTHELIAL-CELLS; INOSITOL LIPID-SYNTHESIS; EXTRACELLULAR-MATRIX; CYTOSKELETAL MECHANICS; INTEGRIN BINDING; CYCLIN D1; GROWTH; SHAPE; TENSEGRITY; ADHESION;
Keywords:
mechanotransduction; cytoskeleton; tensegrity; integrins; cell shape;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Ingber, D Childrens Hosp, Dept Pathol, 300 Longwood Ave, Boston, MA 02115 USA Childrens Hosp 300 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
D. Ingber, "How cells (might) sense microgravity", FASEB J, 13, 1999, pp. S3-S15

Abstract

This article is a summary of a lecture presented at an ESA/NASA Workshop on Cell and Molecular Biology Research in Space that convened in Leuven, Belgium, in June 1998, Recent studies ape reviewed which suggest that cells may sense mechanical stresses, including those due to gravity, through changes in the balance of forces that are transmitted across transmembrane adhesion receptors that link the cytoskeleton to the extracellular matrix and to other cells (e.g., integrins, cadherins, selectins). The mechanism by whichthese mechanical signals are transduced and converted into a biochemical response appears to be based, in part, on the finding that living cells use a tension-dependent form of architecture, known as tensegrity, to organize and stabilize their cytoskeleton, Because of tensegrity, the cellular response to stress differs depending on the level of pre-stress (pre-existing tension) in the cytoskeleton and it involves all three cytoskeletal filament systems as well as nuclear scaffolds. Recent studies confirm that alterations in the cellular force balance can influence intracellular biochemistry within focal adhesion complexes that form at the site of integrin binding aswell as gene expression in the nucleus. These results suggest that gravitysensation may not result from direct activation of any single gravioreceptor molecule. Instead, gravitational forces may be experienced by individualcells in the living organism as a result of stress-dependent changes in cell, tissue, or organ structure that, in turn, alter extracellular matrix mechanics, cell shape, cytoskeletal organization, or internal pre-stress in the cell-tissue matrix.

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Documento generato il 18/01/21 alle ore 15:40:01