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Titolo:
Changes in electrocortical power and coherence in response to the selective cholinergic immunotoxin 192 IgG-saporin
Autore:
Holschneider, DP; Waite, JJ; Leuchter, AF; Walton, NY; Scremin, OU;
Indirizzi:
Univ So Calif, Sch Med, Dept Neurol & Psychiat, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 sychiat, Los Angeles, CA 90033 USA Univ So Calif, Sch Med, Dept Behav Sci, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 hav Sci, Los Angeles, CA 90033 USA Univ Calif San Diego, Dept Neurosci, San Diego, CA USA Univ Calif San Diego San Diego CA USA , Dept Neurosci, San Diego, CA USA Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, Univ Calif Los Angeles Los Angeles CA USA 90024 iobehav Sci, Los Angeles, Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Dept Vet Affairs Med Ctr, Neurol Res Serv, W Los Angeles, CA USA Dept Vet Affairs Med Ctr W Los Angeles CA USA erv, W Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Physiol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 126, anno: 1999,
pagine: 270 - 280
SICI:
0014-4819(199905)126:2<270:CIEPAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; HIPPOCAMPAL THETA-RHYTHM; RAT BASAL FOREBRAIN; NUCLEUS BASALIS; ENTORHINAL CORTEX; EEG COHERENCE; FUNCTIONAL CONNECTIVITY; EFFERENT CONNECTIONS; ALZHEIMERS-DISEASE; TRANSPORT METHODS;
Keywords:
coherence; entorhinal cortex; cortex; hippocampus; amygdala; 192 IgG-saporin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Holschneider, DP Univ So Calif, Sch Pharm, 1985 Zonal Ave,Rm 512, Los Angeles, CA 90033 USA Univ So Calif 1985 Zonal Ave,Rm 512 Los Angeles CA USA 90033
Citazione:
D.P. Holschneider et al., "Changes in electrocortical power and coherence in response to the selective cholinergic immunotoxin 192 IgG-saporin", EXP BRAIN R, 126(2), 1999, pp. 270-280

Abstract

Changes:in brain electrical activity in response to cholinergic agonists, antagonists, or excitotoxic lesions of the basal forebrain may not be reflective entirely of changes in cholinergic tone, in so far as these interventions also involve noncholinergic neurons. We examined electrocortical activity in rats following bilateral intracerebroventricular administration of 192 IgG-saporin (1.8 mu g/ventricle), a selective cholinergic immunotoxin directed to the low-affinity nerve growth factor receptor p75. The immunotoxin resulted in extensive loss of choline acetyl transferase (ChAT) activity in neocortex (80%-84%) and hippocampus (93%), with relative sparing of entorhinal-piriform cortex (42%) and amygdala (28%). Electrocortical activity demonstrated modest increases in 1- to 4-Hz power, decreases in 20- to 44-Hzpower, and decreases in 4- to 8-Hz intra- and in- terhemispheric coherence. Rhythmic slow activity (RSA) occurred robustly in toxin-treated animals during voluntary movement and in response to physostigmine, with no significant differences seen in power and peak frequency in comparison with controls. Physostigmine significantly increased intrahemispheric coherence in lesioned and intact animals, with minor increases seen in interhemispheric coherence. Our study suggests that: (1) electrocortical changes in response to selective cholinergic deafferentation are more modest than those previouslyreported following excitotoxic lesions; (2) changes in cholinergic tone affect primarily brain electrical transmission within, in contrast to betweenhemispheres; and (3) a substantial cholinergic reserve remains following administration of 192 IgG-saporin, despite dramatic losses of ChAT in cortexand hippocampus. Persistence of a cholinergically modulated RSA suggests that such activity may be mediated through cholinergic neurons which, because they lack the p75 receptor, remain unaffected by the immunotoxin.

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Documento generato il 05/04/20 alle ore 09:49:50