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Titolo:
Effects of paxilline on K+ channels in rat mesenteric arterial cells
Autore:
Li, GD; Cheung, DW;
Indirizzi:
Univ Ottawa, Inst Heart, Ottawa, ON K1Y 4W9, Canada Univ Ottawa Ottawa ONCanada K1Y 4W9 st Heart, Ottawa, ON K1Y 4W9, Canada
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 372, anno: 1999,
pagine: 103 - 107
SICI:
0014-2999(19990507)372:1<103:EOPOKC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ACTIVATED POTASSIUM CHANNELS;
Keywords:
paxilline; K+ channel; Ca2+-activated; smooth muscle; vascular; iberiotoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Cheung, DW Univ Ottawa, Inst Heart, 40 Ruskin St, Ottawa, ON K1Y 4W9, Canada Univ Ottawa 40 Ruskin St Ottawa ON Canada K1Y 4W9 Y 4W9, Canada
Citazione:
G.D. Li e D.W. Cheung, "Effects of paxilline on K+ channels in rat mesenteric arterial cells", EUR J PHARM, 372(1), 1999, pp. 103-107

Abstract

The effects of paxilline, a mycotoxin, on whole-cell outward currents fromfreshly isolated cells of the rat mesenteric artery were studied. Paxilline inhibited a component of the outward current that was also sensitive to iberiotoxin. Inhibition could be observed at a concentration of 10 nM and complete inhibition of the iberiotoxin-sensitive current was achieved at 300 nM. The inhibition could be described by a single site of interaction with a K-i of 35.7 nM. Paxilline had no effect on the component of the current that was sensitive to 4-aminopyridine. It is concluded that paxilline is a potent inhibitor of large conductance Ca2+-activated K+ currents in vascularsmooth muscle cells. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 23:11:02