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Titolo:
The kinetics of beta-methyl-substituted labelled fatty acids in ischaemic myocardium: an analysis in man and with a blood-perfused isolated heart model
Autore:
Marie, PY; Menu, P; Angioi, M; Mertes, PM; Ayalew, A; Hassan, N; Olivier, P; Fagret, D; Karcher, G; Danchin, N; Pasqualini, R; Bertrand, A;
Indirizzi:
CHU Nancy, UPRESA EA 2403, Dept Nucl Med, Nancy, France CHU Nancy Nancy France cy, UPRESA EA 2403, Dept Nucl Med, Nancy, France CHU Nancy, UPRESA EA 2403, Dept Cardiol, Nancy, France CHU Nancy Nancy France ncy, UPRESA EA 2403, Dept Cardiol, Nancy, France Univ Henri Poincare, Sch Pharm, Dept Hematol & Physiol, Nancy, France UnivHenri Poincare Nancy France Dept Hematol & Physiol, Nancy, France CHU Grenoble, Dept Nucl Med, F-38043 Grenoble, France CHU Grenoble Grenoble France F-38043 Nucl Med, F-38043 Grenoble, France CIS Bio Int, Gif Sur Yvette, France CIS Bio Int Gif Sur Yvette FranceCIS Bio Int, Gif Sur Yvette, France
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 26, anno: 1999,
pagine: 474 - 482
SICI:
0340-6997(199905)26:5<474:TKOBLF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPTADECANOIC ACID; ISCHEMIC MYOCARDIUM; EMISSION TOMOGRAPHY; REST-REINJECTION; WALL-MOTION; RAT-HEART; METABOLISM; INFARCTION; TL-201; VIABILITY;
Keywords:
ischaemia; free fatty acids; methyl-branched fatty acids; thallium-201; single-photon emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Marie, PY CHU Nancy Brabois, Nucl Med Serv, F-54511 Vandoeuvre Nancy, France CHU Nancy Brabois Vandoeuvre Nancy France F-54511 ancy, France
Citazione:
P.Y. Marie et al., "The kinetics of beta-methyl-substituted labelled fatty acids in ischaemic myocardium: an analysis in man and with a blood-perfused isolated heart model", EUR J NUCL, 26(5), 1999, pp. 474-482

Abstract

beta-Methyl-substituted free fatty acids (FFAs) have been developed for myocardial single-photon emission tomography (SPET) imaging, but little is known about their kinetics in ischaemic conditions. The aim of this study wasto determine the changes in the myocardial kinetics of a beta-methyl-branched FFA, [I-123]16-iodo-3-methyl-hexadecanoic acid (MIHA), under ischaemic conditions. The kinetics of MIHA were analysed: (a) using a blood-perfused isolated heart model subjected to moderate ischaemia (50% flow reduction) and (b) in patients who had an exercise thallium-201 SPET defect corresponding to either necrotic (n = 13) or chronically ischaemic and viable (II = 15) myocardium, and who underwent two consecutive SPET studies after MIHA injection. In animals, the myocardial early retention fraction of MIHA, but not its clearance rate, was dependent on coronary flow, the early retention fraction being higher in ischaemic than in normoxic conditions (0.24 +/- 0.10 vs 0.14 +/- 0.04, P = 0.004). In the patient SPET studies, the uptake of MIHA calculated in ischaemic and viable areas (G1: 74% +/- 9% of maximal left ventricular value) was different from that calculated in necrotic (G2: 59% +/- 7%, P < 0.001) or normal (G3: 88 +/- 6%, P < 0.001) areas. By contrast, MIHA-clearance calculated between the two consecutive SPET studies was not different in G1, G2 and G3. Unlike in the case of other FFAs, the myocardial clearance of MIHA is not decreased by ischaemia, However, the early retention of MIHA is increased in the case of a moderate reduction in coronary flow, a property which might help in the detection of viability in chronically ischaemic myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:19:06