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Titolo:
Respective roles of scatter, attenuation, depth-dependent collimator response and finite spatial resolution in cardiac single-photon emission tomography quantitation: a Monte Carlo study
Autore:
El Fakhri, GN; Buvat, I; Pelegrini, M; Benali, H; Almeida, P; Bendriem, B; Todd-Pokropek, A; Di Paola, R;
Indirizzi:
CHU Pitie Salpetriere, U494 INSERM, F-75634 Paris 13, France CHU Pitie Salpetriere Paris France 13 4 INSERM, F-75634 Paris 13, France SHFJ, Grp Instrumentat PET SPET, F-91401 Orsay, France SHFJ Orsay FranceF-91401 p Instrumentat PET SPET, F-91401 Orsay, France
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 26, anno: 1999,
pagine: 437 - 446
SICI:
0340-6997(199905)26:5<437:RROSAD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECT QUANTIFICATION; RECONSTRUCTION; COMPENSATION; IMAGES; ACCURACY;
Keywords:
quantitation; cardiac single-photon emission tomography Monte Carlo simulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Buvat, I CHU Pitie Salpetriere, U494 INSERM, 91 Blvd Hop, F-75634 Paris 13, France CHU Pitie Salpetriere 91 Blvd Hop Paris France 13 ris 13, France
Citazione:
G.N. El Fakhri et al., "Respective roles of scatter, attenuation, depth-dependent collimator response and finite spatial resolution in cardiac single-photon emission tomography quantitation: a Monte Carlo study", EUR J NUCL, 26(5), 1999, pp. 437-446

Abstract

The purpose of this study was to investigate the relative influence of scatter, attenuation, depth-dependent collimator response and finite spatial resolution upon the image characteristics in cardiac single-photon emission tomography (SPET). An acquisition of an anthropomorphic cardiac phantom wasperformed together with corresponding SPET Monte Carlo simulations. The cardiac phantom and the Monte Carlo simulations were designed so that the effect of scatter, attenuation, depth-dependent collimator response and finitespatial resolution could be studied individually and in combination. The impact of each physical effect and of combinations of effects was studied interms of absolute and relative quantitative accuracy, spatial resolution and signal-to-noise ratio (SNR) in the resulting images. No corrections for these effects were assessed. Results obtained from Monte Carlo simulations and real acquisitions were in excellent agreement. Attenuation introduced about 90% activity underestimation in a 10-mm-thick left ventricle wall while finite spatial resolution alone introduced about 30% activity underestimation. Scatter had a negligible impact on quantitative accuracy in the recontructed slices when attenuation was present. Neither bull's eye map homogeneity nor contrast between a hot and a cold region were affected by depth-dependent collimator response or finite spatial resolution. Bull's eye map homogeneity was severely affected by attenuation but not by scatter. Attenuation and scatter reduced contrast by about 20% each. Both attenuation and scatter increased the full-width at half-maximum (FWHM) characterizing the spatial resolution of the imaging system by approximate to 1 mm each but the main effect responsible for the observed 11-mm FWHM spatial resolution was the depth-dependent collimator response. SNR was reduced by a factor of approximate to 2.5 because of attenuation, while scattered counts increased SNR by approximate to 10%. In conclusion, the quantification of the relative influence of the different physical effects showed that attenuation is definitely the major phenomenon affecting cardiac SPET imaging accuracy, but that finite spatial resolution, scatter and depth-dependent collimator response also contribute significantly to the errors in absolute and relative quantitation and to the poor spatial resolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 20:55:41