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Titolo:
CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles
Autore:
Brocker, T; Gulbranson-Judge, A; Flynn, S; Riedinger, M; Raykundalia, C; Lane, P;
Indirizzi:
Univlandmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, Eng Univ Birmingham Birmingham W Midlands England B15 2TT TT, W Midlands, Eng Max Planck Inst Immunbiol, D-7800 Freiburg, Germany Max Planck Inst Immunbiol Freiburg Germany D-7800 7800 Freiburg, Germany Basel Inst Immunol, Basel, Switzerland Basel Inst Immunol Basel Switzerland l Inst Immunol, Basel, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 29, anno: 1999,
pagine: 1610 - 1616
SICI:
0014-2980(199905)29:5<1610:CTCTCI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; CHEMOKINE RECEPTOR; LIGAND; ACTIVATION; ANTIGEN; DIFFERENTIATION; LYMPHOCYTES; T-HELPER-1; MOLECULE; SPLEEN;
Keywords:
Th1-Th2 differentiation; OX40/OX40-ligand; cytokine; chemokine; T cell migration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Lane, P Unividlands,ham, Sch Med, Dept Immunol, Vincent Dr, Birmingham B152TT, W M Univ Birmingham Vincent Dr Birmingham W Midlands England B15 2TT M
Citazione:
T. Brocker et al., "CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles", EUR J IMMUN, 29(5), 1999, pp. 1610-1616

Abstract

We report here that CD40- but not lipopolysaccharide (LPS)-activated murine dendritic cells (DG) express OX40-ligand (OX40L) as has been: reported inhumans. To understand how OX40 ligation affects differentiation of CD4 T cells at the time of priming, we constitutively expressed OX40L on DG using the DC-specific promoter of CD11c. Transgenic mice showed greatly increasednumbers of CD4 but not CD8 T cells in their B cell areas. This effect was to a great extent immunization dependent, as spleen and lymphoid tissue with no germinal center reactions from mice which had not been deliberately immunized did not show marked CD4 T cell accumulation. The increased numbers of CD4(+) CD62(low) cells in transgenic mice suggest that it: is activated CD4 T cells that accumulate within B cell follicles. These data are consistent with the notion that physiological engagement of OX40 (CD134) on activated CD4 T cells either initiates their migration into or causes them to be retained in B follicles. In contrast, LPS-treated CD did not up-regulate OX40L expression. This dichotomy provides a molecular explanation of how DC might integrate environmental and accessory signals to control cytokine differentiation and migration in CD4 effector cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:43:11