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Titolo:
Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions
Autore:
Taams, LS; van Eden, W; Wauben, MHM;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Immunol, Inst Infect Dis & Immunol, NL-3508 Univ Utrecht Utrecht Netherlands NL-3508 TD nfect Dis & Immunol, NL-3508
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 29, anno: 1999,
pagine: 1543 - 1550
SICI:
0014-2980(199905)29:5<1543:APBTCV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTES-T; OX40 LIGAND; RECEPTOR; PROLIFERATION; EXPRESSION; ARTHRITIS;
Keywords:
anergy; T cell; antigen presentation; OX40; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Wauben, MHM Univ65,recht, Fac Vet Med, Dept Immunol, Inst Infect Dis & Immunol, POB 801 Univ Utrecht POB 80165 Utrecht Netherlands NL-3508 TD POB 801
Citazione:
L.S. Taams et al., "Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions", EUR J IMMUN, 29(5), 1999, pp. 1543-1550

Abstract

We compared the effects of antigen (Ag) presentation by T cells and professional antigen-presenting cells (APC) on T cell proliferation, cytokine production and surface molecule expression. Ag presentation by T cells (T-T presentation) induced an initial T cell activation phase as measured by proliferation and IL-2 production. These activated T cells became anergic upon antigenic restimulation by professional APC, as shown by a failure to proliferate or produce IL-2 or IFN-gamma. Interestingly, such T cells were not intrinsically defective in their signal transduction pathways since they did proliferate and produce cytokines upon restimulation with mitogenic stimuli. Flow cytometric analysis revealed a more profound TCR and CD3 down-regulation during T-T presentation than during APC-T presentation. However, no up-regulation of CD80, CD86, CD45RC and OX40 (CD134) was observed on T cells during T-T presentation or subsequent antigenic restimulation of anergic T cells in the presence of professional APC, whereas increased expression of these molecules was observed during professional APC-T presentation of non-anergic T cells. The impaired expression of costimulatory and activation molecules on T cells after T-T presentation of Ag might lead to altered interactions between T cells and professional APC upon antigenic restimulation. We propose that T cell anergy is a functional consequence of these altered T cell-APC interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:56:54