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Titolo:
NATURAL-KILLER AND LYMPHOKINE-ACTIVATED CYTOTOXICITY FOLLOWING ANESTHESIA IN PATIENTS WITH UVEAL MALIGNANT-MELANOMA
Autore:
RICHARDSON PSR; COOKE K; GERRISH P; REES RC; RENNIE IG;
Indirizzi:
UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT OPHTHALMOL & ORTHOP SHEFFIELD S10 2JF S YORKSHIRE ENGLAND UNIV SHEFFIELD,INST CANC STUDIES SHEFFIELD S10 2JF S YORKSHIRE ENGLAND ROYAL HALLAMSHIRE HOSP,DEPT ANAESTHESIA SHEFFIELD S10 2JF S YORKSHIREENGLAND NOTTINGHAM TRENT UNIV,DEPT LIFE SCI NOTTINGHAM NG1 4BU ENGLAND
Titolo Testata:
Melanoma research
fascicolo: 2, volume: 7, anno: 1997,
pagine: 129 - 137
SICI:
0960-8931(1997)7:2<129:NALCFA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-ENUCLEATION IRRADIATION; CYTO-TOXICITY; LYMPHOCYTIC INFILTRATION; PREENUCLEATION RADIATION; CHOROIDAL MELANOMAS; CANCER-PATIENTS; CELL-ACTIVITY; DISEASE; SURGERY; METASTASIS;
Keywords:
ANESTHESIA; IMMUNOSUPPRESSION; LYMPHOCYTE-ACTIVATED CELLS; NATURAL KILLER CELLS; UVEAL MALIGNANT MELANOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
P.S.R. Richardson et al., "NATURAL-KILLER AND LYMPHOKINE-ACTIVATED CYTOTOXICITY FOLLOWING ANESTHESIA IN PATIENTS WITH UVEAL MALIGNANT-MELANOMA", Melanoma research, 7(2), 1997, pp. 129-137

Abstract

The role of enucleation in the treatment of ocular melanoma has been questioned by those who believe that it may increase circulating melanoma cells, increasing the incidence of metastases. Some aspects of theimmune system are depressed by general anaesthesia, therefore this study was initiated to assess the effect of general anaesthesia on natural killer (NK) cell and interleukin-2 (IL-2)-activated cytotoxicity in19 patients using Cr-51-labelled target cells (K 562 and SW 742). NK cytotoxicity was increased at induction and during the operation whichwas due to significant increases in female, but not male patients. At1 week post-surgery, female patients had decreased NK cytotoxicity compared with males at this interval. NK cytotoxicity was increased intra-operatively when alfentanyl was used, and if the mean tumour diameter was > 15.0 mm the NK cytotoxicity was increased intra-operatively compared with that in patients with smaller tumours. IL-2-stimulated cytotoxicity was reduced at 1 day post-surgery in females only. There wasan increased IL-2-stimulated cytotoxicity at induction when propofol was used and IL-2-stimulated cytotoxicity was reduced at 1 week post-operatively if the patient's mean tumour diameter was > 15.0 mm. If NK cell and lymphokine-stimulated cell cytotoxicity are involved in limiting metastatic disease, the patient' sex and tumour size and the anaesthetic agent used may influence the survival rates following surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 18:32:27