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Titolo:
Lupus nephritis in juvenile myelomonocytic leukemia
Autore:
Kitahara, M; Koike, K; Kurokawa, Y; Sawai, N; Mori, T; Nakazawa, K; Shigematsu, H; Komiyama, A;
Indirizzi:
Shinshu Univ, Dept Pediat, Sch Med, Matsumoto, Nagano 3900802, Japan Shinshu Univ Matsumoto Nagano Japan 3900802 sumoto, Nagano 3900802, Japan Shinshu Univ, Dept Pathol, Sch Med, Matsumoto, Nagano 3900802, Japan Shinshu Univ Matsumoto Nagano Japan 3900802 sumoto, Nagano 3900802, Japan
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 5, volume: 51, anno: 1999,
pagine: 314 - 318
SICI:
0301-0430(199905)51:5<314:LNIJML>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; AUTOIMMUNE-DISEASES; TRANSPLANTATION; MONOSOMY-7; CULTURE; CELLS;
Keywords:
juvenile myelomonocytic leukemia (JMML); lupus nephritis; systemic lupus erythematosus (SLE); Hashimoto thyroiditis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kitahara, M Shinshu Univ, Dept Pediat, Sch Med, 3-1-1 Asahi, Matsumoto, Nagano 3900802, Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3900802 00802,
Citazione:
M. Kitahara et al., "Lupus nephritis in juvenile myelomonocytic leukemia", CLIN NEPHR, 51(5), 1999, pp. 314-318

Abstract

A 13-year-old girl developed lupus nephritis and Hashimoto thyroiditis in the chronic phase of juvenile myelomonocytic leukemia (JMML). At age 7 months, she was diagnosed as having JMML based on the hepatosplenomegaly, leukocytosis, thrombocytopenia, increased levels of fetal hemoglobin, and spontaneous in vitro growth of granulocyte-macrophage progenitors. At the onset of JMML, she had hypergammaglobulinemia, antinuclear antibodies, rheumatoid factors and anti-smooth muscle antibody. She had been placed on oral 6-mercaptopurine for about 12 years, with clinical improvement. At age 13 years, she was found to have hematuria and proteinuria. She also developed arthritis and Raynaud's phenomenon as well. She had antinuclear antibodies, rheumatoid factors, LE phenomenon, beta-1C (C3) nephritic factor (C3NeF), antithyroid antibodies, and hypocomplementemia. The renal biopsy specimens revealed a diffuse increase in the mesangial cells and matrix by light microscopy,and intense staining of IgG, C1q and C3 by immunofluorescence microscopy. The hormonal study ultimately showed decreased thyroid functions, So she was diagnosed as lupus nephritis and Hashimoto thyroiditis. The patient is the first example to show close relationship between stem cell abnormalities in JMML and development of overt autoimmune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:24:49