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Titolo:
Development and application of adenoviral vectors for gene therapy of cancer
Autore:
Zhang, WW;
Indirizzi:
GenStar Therapeut Corp, San Diego, CA 92121 USA GenStar Therapeut Corp San Diego CA USA 92121 rp, San Diego, CA 92121 USA
Titolo Testata:
CANCER GENE THERAPY
fascicolo: 2, volume: 6, anno: 1999,
pagine: 113 - 138
SICI:
0929-1903(199903/04)6:2<113:DAAOAV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENE; WILD-TYPE P53; DNA-BINDING PROTEIN; REPLICATION-COMPETENT ADENOVIRUS; FULL-LENGTH DYSTROPHIN; CRE-MEDIATED EXCISION; PACKAGING CELL-LINES; PENTON BASE PROTEIN; ENCODING HUMAN P53; RAT EMBRYO CELLS;
Keywords:
adenoviral vector; cancer gene therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
240
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, WW GenStar Therapeut Corp, 10835 Altman Row,Suite 150, San Diego, CA 92121 USA GenStar Therapeut Corp 10835 Altman Row,Suite 150 San Diego CA USA 92121
Citazione:
W.W. Zhang, "Development and application of adenoviral vectors for gene therapy of cancer", CANC GENE T, 6(2), 1999, pp. 113-138

Abstract

For successful gene vaccination and therapy of cancer, it is essential to develop gene delivery vectors that can meet clinical and social requirements. The need for improved vectors was clearly manifested during the peak of the first wave of gene therapy. Adenoviral (Ad) vectors have recently drawnthe attention of many of those involved in the field of gene therapy for cancer because of their practical advantages and application potential. Manyexperiments, innovations, preclinical studies, and clinical trials have generated an overwhelming amount of data and literature concerning this vector system. It is hoped that the comprehensive review presented here, which includes the principles, potential, capacity, and limitations of the currentAd systems, will help to further the rational development of the system. The literature in this article is organized in an attempt to emphasize Ad vector development in the aspects of technical approaches, practical hurdles and strategies to overcome them, significant experimental results, recent advances, future directions, etc. The technical range of this review covers details that are intended to serve as a reference for advanced technical readers and provide a foundation for initiates in the field of Ad vector genetherapy. The material presented here is also intended for nontechnical persons who want to have an overview of the significance and potential of the technology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:05:50