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Titolo:
Increase in apoptosis and concomitant reduction of ischemic lesion volume and evidence for synaptogenesis after transient focal cerebral ischemia in rat treated with staurosporine
Autore:
Chopp, M; Li, Y; Jiang, N;
Indirizzi:
HenryAFord Hosp, Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 US Henry Ford Hosp Detroit MI USA 48202 r, Dept Neurol, Detroit, MI 48202 US Oakland Univ, Dept Phys, Rochester, MI 48309 USA Oakland Univ Rochester MI USA 48309 v, Dept Phys, Rochester, MI 48309 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 828, anno: 1999,
pagine: 197 - 201
SICI:
0006-8993(19990515)828:1-2<197:IIAACR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; MICROTUBULE-ASSOCIATED PROTEIN-2; PROGRAMMED CELL-DEATH; NEURONAL DAMAGE; INHIBITOR;
Keywords:
apoptosis; synaptogenesis; tissue plasticity; rat; staurosporine; middle cerebral artery occlusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chopp, M Henryetroit,osp, Henry Ford Hlth Sci Ctr, Dept Neurol, 2799 W Grand Blvd, D Henry Ford Hosp 2799 W Grand Blvd Detroit MI USA 48202 nd Blvd, D
Citazione:
M. Chopp et al., "Increase in apoptosis and concomitant reduction of ischemic lesion volume and evidence for synaptogenesis after transient focal cerebral ischemia in rat treated with staurosporine", BRAIN RES, 828(1-2), 1999, pp. 197-201

Abstract

We sought to determine whether induction of apoptosis alters an ischemic lesion. Rats were subjected to 2 h of middle cerebral artery occlusion (MCAo) and treated with staurosporine (n = 8) or vehicle (n = 4). Our data demonstrate that at 22 h after MCAo, staurosporine triggered a significant increase in apoptosis, a reduction of lesion volume and an increase of synaptophysin immunoreactivity, as compared to the control group. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:47:47