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Titolo:
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
Autore:
Cordi, A; Lacoste, JM; Audinot, V; Millan, M;
Indirizzi:
Inst Rech Servier, F-92150 Suresnes, France Inst Rech Servier Suresnes France F-92150 vier, F-92150 Suresnes, France Inst Rech Servier, F-78290 Croissy Sur Seine, France Inst Rech Servier Croissy Sur Seine France F-78290 ssy Sur Seine, France
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 10, volume: 9, anno: 1999,
pagine: 1409 - 1414
SICI:
0960-894X(19990517)9:10<1409:DSASRO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; PARTIAL AGONIST; MODULATORY SITE; NMDA RECEPTOR; D-CYCLOSERINE; COMPLEX; RECOGNITION; ANTAGONIST; L-687,414; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cordi, A Inst Rech Servier, 11 Rue des Moulineaux, F-92150 Suresnes, France Inst Rech Servier 11 Rue des Moulineaux Suresnes France F-92150
Citazione:
A. Cordi et al., "Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands", BIOORG MED, 9(10), 1999, pp. 1409-1414

Abstract

The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a)was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site. (C)1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:41:27