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Titolo:
Developmental traumatology Part II: Brain development
Autore:
De Bellis, MD; Keshavan, MS; Clark, DB; Casey, BJ; Giedd, JN; Boring, AM; Frustaci, K; Ryan, ND;
Indirizzi:
UnivPittsburgh,, Med Ctr, Western Psychiat Inst & Clin, Dev Traumatol Lab,Univ Pittsburgh Pittsburgh PA USA 15213 t Inst & Clin, Dev Traumatol Lab, NIMH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Bethesda, MD 20892 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 45, anno: 1999,
pagine: 1271 - 1284
SICI:
0006-3223(19990515)45:10<1271:DTPIBD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; SCHOOL-AGE-CHILDREN; SEXUALLY ABUSED GIRLS; HUMAN CORPUS-CALLOSUM; HIPPOCAMPAL VOLUME; VENTRICULAR ENLARGEMENT; MALTREATED CHILDREN; MEMORY DYSFUNCTION; PREFRONTAL CORTEX; COMBAT VETERANS;
Keywords:
posttraumatic Stress Disorder (PTSD); child maltreatment; neurodevelopment; corpus callosum; hippocampus; intracranial volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: De Bellis, MD Univ3811tsburgh, Med Ctr, Western Psychiat Inst & Clin, Dev Traumatol Lab, Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 l Lab,
Citazione:
M.D. De Bellis et al., "Developmental traumatology Part II: Brain development", BIOL PSYCHI, 45(10), 1999, pp. 1271-1284

Abstract

Background: Previous investigations suggest that maltreated children with a diagnosis of posttraumatic stress disorder (PTSD) evidence alterations ofbiological stress systems. Increased levels of catecholaminergic neurotransmitters and steroid hormones during traumatic experiences in childhood could conceivably adversely affect brain development. Methods: In this study, 44 maltreated children and adolescents with PTSD and 61 matched controls underwent comprehensive psychiatric and neuropsychological assessments and an anatomical magnetic resonance imaging (MRI) brainscan. Results: PTSD subjects had smaller intracranial and cerebral volumes than marched controls, The total midsagittal area of corpus callosum and middle and posterior regions remained smaller; while right, left, and total lateral ventricles were proportionally larger than controls, after adjustment forintracranial volume. Brain volume robustly and positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse. Symptoms of intrusive thoughts, avoidance, hyperarousal or dissociation correlated positively with ventricular volume, and negatively with brain volume and total corpus callosum and regional measures, Significant gender bydiagnosis effect revealed greater corpus callosum al-ea reduction in maltreated males with PTSD and a trend for greater cerebral volume reduction than maltreated females with PTSD. The predicted decrease in hippocampal volume seen in adult PTSD was not seen in these subjects. Conclusions: These data suggest that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development. Biol Psychiatry 1999;45:1271-1284 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 16/01/21 alle ore 07:37:21