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Titolo:
Developmental traumatology Part I: Biological stress systems
Autore:
De Bellis, MD; Baum, AS; Birmaher, B; Keshavan, MS; Eccard, CH; Boring, AM; Jenkins, FJ; Ryan, ND;
Indirizzi:
UnivPittsburgh,, Med Ctr, Western Psychiat Inst & Clin, Dev Traumatol Lab,Univ Pittsburgh Pittsburgh PA USA 15213 t Inst & Clin, Dev Traumatol Lab, Pittsburgh Canc Inst, Pittsburgh, PA 15213 USA Pittsburgh Canc Inst Pittsburgh PA USA 15213 st, Pittsburgh, PA 15213 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 45, anno: 1999,
pagine: 1259 - 1270
SICI:
0006-3223(19990515)45:10<1259:DTPIBS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY CATECHOLAMINE EXCRETION; MAJOR DEPRESSIVE DISORDER; SEXUALLY ABUSED GIRLS; SCHOOL-AGE-CHILDREN; MALTREATED CHILDREN; CORTISOL SECRETION; ADOLESCENTS; RELIABILITY; SCHIZOPHRENIA; ACTIVATION;
Keywords:
child maltreatment; posttraumatic stress disorder (PTSD); urinary catecholamines; cortisol; overanxious disorder (OAD); sexual abuse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: De Bellis, MD Univ3811tsburgh, Med Ctr, Western Psychiat Inst & Clin, Dev Traumatol Lab, Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 l Lab,
Citazione:
M.D. De Bellis et al., "Developmental traumatology Part I: Biological stress systems", BIOL PSYCHI, 45(10), 1999, pp. 1259-1270

Abstract

Background: This investigation examined the relationship between trauma, psychiatric symptoms and urinary free cortisol (UFC) and catecholamine (epinephrine [EPI] norepinephrine [NE], dopamine [DA]) excretion in prepubertal children with posttraumatic stress disorder (PTSD) secondary to past child maltreatment experiences (n = 18), compared to non-traumatized children with over-anxious disorder (OAD) (n = 10) and healthy controls (n = 24),Methods: Subjects underwent comprehensive psychiatric and clinical assessments and 24 hour urine collection for measurements of UFC and urinary catecholamine excretion. Biological and clinical measures were compared using analyses of variance. Results: Maltreated subjects with PTSD excreted significantly greater concentrations of urinary DA and NE over 24 hours than OAD and control subjectsand greater concentrations of 24 hour UFC than control subjects. Post hoc analysis revealed that maltreated subjects with PTSD excreted significantlygreater concentrations of urinary EPI than OAD subjects. Childhood PTSD was associated with greater co-morbid psychopathology including depressive and dissociative symptoms, lower global assessment of functioning, and increased incidents of lifetime suicidal ideation and attempts. Urinary catecholamine and UFC concentrations showed positive correlations with duration of the PTSD trauma and severity of PTSD symptoms. Conclusions: These data suggest that maltreatment experiences are associated with alterations of biological stress systems in maltreated children with PTSD. An improved psychobiological understanding of trauma in childhood may eventually lead to better treatments of childhood PTSD. Biol Psychiatry 1999;45:1259-1270 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 15/07/20 alle ore 19:56:06