Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLUENCE OF THE DISINTEGRANT ON THE DRUG PERCOLATION-THRESHOLD IN TABLETS
Autore:
CARABALLO I; FERNANDEZAREVALO M; MILLAN M; ALVAREZFUENTES J; RABASCO AM;
Indirizzi:
UNIV SEVILLA,FAC PHARM,DEPT PHARMACEUT TECHNOL E-41012 SEVILLE SPAIN
Titolo Testata:
Drug development and industrial pharmacy
fascicolo: 7, volume: 23, anno: 1997,
pagine: 665 - 669
SICI:
0363-9045(1997)23:7<665:IOTDOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSAGE FORM DESIGN; FRACTAL GEOMETRY; SYSTEMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
I. Caraballo et al., "INFLUENCE OF THE DISINTEGRANT ON THE DRUG PERCOLATION-THRESHOLD IN TABLETS", Drug development and industrial pharmacy, 23(7), 1997, pp. 665-669

Abstract

Previous papers studied ternary tablets containing different concentrations of polyvinylpyrrolidone cross-link (PVP-CL) as disintegrant. The drug percolation threshold, p(cl), for these tablets was estimated to fall in the range 0.26-0.31 of total porosity. The aim of the present paper is to study if the presence of the disintegrant agent (PVP-CL)in these tablets, exerts an important effect on the drug percolation threshold obtained. For this purpose, binary tablets containing the same model drug and excipient have been prepared in identical technological conditions. The drug percolation threshold in these matrix tabletshas been calculated following the method of Bonny and Leuenberger (5). The results obtained show no significant difference between p(cl) inthe binary matrix tablets and the drug percolation threshold found inthe tablets containing the disintegrant agent. This result supposes astimulus for the application of the principles of percolation theory to a great number of pharmaceutical systems containing disintegrant agents or substances which cause a strong change in its release behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:10:02