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Titolo:
Extracellular matrix and integrin signalling: the shape of things to come
Autore:
Boudreau, J; Jones, PL;
Indirizzi:
Univ Calif San Francisco, Surg Res Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Univ Penn, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104Univ Penn, Philadelphia, PA 19104 USA
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 339, anno: 1999,
parte:, 3
pagine: 481 - 488
SICI:
0264-6021(19990501)339:<481:EMAIST>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR RECEPTOR; MAMMARY EPITHELIAL-CELLS; HUMAN ENDOTHELIAL-CELLS; SMALL GTPASE-RHO; TYROSINE KINASE; MAP KINASE; GENE-EXPRESSION; BASEMENT-MEMBRANE;
Keywords:
anchorage-dependent growth; cell shape; focal adhesion kinase; integrins; mitogen-activated kinase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Boudreau, J Univ Calif San Francisco, Surg Res Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
J. Boudreau e P.L. Jones, "Extracellular matrix and integrin signalling: the shape of things to come", BIOCHEM J, 339, 1999, pp. 481-488

Abstract

The extracellular matrix (ECM) and integrins collaborate to regulate gene expression associated with cell growth, differentiation and survival. Biochemical and molecular analyses of integrin signalling pathways have uncovered several critical cytoplasmic proteins that link the ECM and integrins to intracellular pathways that may contribute to anchorage-dependent growth. Alarge body of evidence now indicates that the nonreceptor protein kinases focal adhesion kinase (FAK) and specific members of the mitogen-activated protein kinases (MAPKs), including the extracellular-signal-regulated kinases (ERKs), mediate these ECM- and integrin-derived signalling events. However, little is known about how FAK and MAPKs contribute to biological processes other than cell proliferation or migration. In addition, remarkably little is known concerning the signalling events that occur in cells that adhere to complex multivalent extracellular matrices via multiple integrin receptors. Given the stringent requirement for attaining a proper morphology in ECM/integrin-directed cell behaviour, it is still not clear how cell shape and tissue architecture impact upon intracellular signalling programmes involving FAK and MAPKs. However, the recent discovery that members of the Rhofamily of small GTPases are able to regulate ECM/integrin pathways that modulate both cell shape and intracellular signalling provides new insights into how cell morphology and signal transduction become integrated, especially within three-dimensional differentiated tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:33:57