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Titolo:
Metabolic studies of [F-18-alpha-methyl]tyrosine in mice bearing colorectal carcinoma LS-180
Autore:
Tomiyoshi, K; Inoue, T; Higuchi, T; Ahmed, K; Sarwar, M; Alyafei, S; Zhang, H; Matsubara, K; Endo, K; Yang, D;
Indirizzi:
UnivSAexas, MD Anderson Canc Ctr, Div Diagnost Imaging, Houston, TX 77030 U Univ Texas Houston TX USA 77030 Div Diagnost Imaging, Houston, TX 77030 U Gunma Univ, Sch Med, Dept Nucl Med, Maebashi, Gumma 371, Japan Gunma UnivMaebashi Gumma Japan 371 Nucl Med, Maebashi, Gumma 371, Japan
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 3, volume: 10, anno: 1999,
pagine: 329 - 336
SICI:
0959-4973(199903)10:3<329:MSO[IM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-TRANSPORT; ALPHA-METHYL TYROSINE; PROTEIN-SYNTHESIS; BRAIN-TUMORS; PET; INVIVO; SPECT;
Keywords:
colorectal carcinoma; [F-18-alpha-methyl]tyrosine; imaging; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, D Univ Texas, MD Anderson Canc Ctr, Div Diagnost Imaging, 1515 Holcombe Blvd, Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 Holcombe Blvd,
Citazione:
K. Tomiyoshi et al., "Metabolic studies of [F-18-alpha-methyl]tyrosine in mice bearing colorectal carcinoma LS-180", ANTI-CANC D, 10(3), 1999, pp. 329-336

Abstract

Brain and tumor uptake of [F-18-alpha-methyl]tyrosine (F-18-AMT) and the incorporation into each of four fractions (lipid, RNA, DNA and protein) wereinvestigated in mice bearing LS180 colorectal carcinoma, Homogenized tissues were analyzed by the fractionation method into an acid-soluble fraction (ASF) and an acid-precipitable fraction (APF). The APF was further investigated to assess the incorporation of F-18-AMT into each fraction. Incorporation into four fractions of brain and tumor at 60 min post-injection was 20 and 12%, respectively; 10% of the activity was incorporated to lipid in brain and 5% in tumor. There was 5, 2 and 2% incorporation with RNA, DNA and protein, respectively. Metabolites in ASF were analyzed by high-performance liquid chromatography and thin-layer chromatography. There was only one radioactive peak, which corresponded to F-18-AMT. The incorporation of F-18-AMT into lipid was twice that of F-18-AMT in tumor. The uptake of F-18-AMT intissues was rapid and accomplished before 30 min, and then slowly diffusedin blood. These results implied that F-18-AMT was metabolized to protein to only a small extent and trapped as intact F-18-AMT in cells up to 60 min. We conclude that F-18-AMT is a promising tracer for tumor imaging and quantification of the transport rate using two-compartment models. [(C) 1999 Lippincott Williams & Wilkins.].

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Documento generato il 20/01/21 alle ore 02:18:19